ID   YQ12_CAEEL              Reviewed;        1523 AA.
AC   Q09449;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Uncharacterized ATP-dependent helicase C05C10.2;
DE            EC=3.6.4.-;
GN   ORFNames=C05C10.2 {ECO:0000312|WormBase:C05C10.2a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284602; CAA88201.2; -; Genomic_DNA.
DR   PIR; T18941; T18941.
DR   RefSeq; NP_496142.1; NM_063741.4.
DR   AlphaFoldDB; Q09449; -.
DR   SMR; Q09449; -.
DR   BioGRID; 39868; 1.
DR   IntAct; Q09449; 1.
DR   STRING; 6239.C05C10.2b.1; -.
DR   PaxDb; Q09449; -.
DR   PeptideAtlas; Q09449; -.
DR   EnsemblMetazoa; C05C10.2a.1; C05C10.2a.1; WBGene00007329.
DR   UCSC; C05C10.2a; c. elegans.
DR   WormBase; C05C10.2a; CE53934; WBGene00007329; -.
DR   eggNOG; KOG1801; Eukaryota.
DR   InParanoid; Q09449; -.
DR   PRO; PR:Q09449; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00007329; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q09449; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043186; C:P granule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10887; PTHR10887; 4.
DR   Pfam; PF13087; AAA_12; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1523
FT                   /note="Uncharacterized ATP-dependent helicase C05C10.2"
FT                   /id="PRO_0000080727"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1463..1498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         993..1000
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1523 AA;  172265 MW;  A662858D96636B0D CRC64;
     MLPTSSNNEE NRKPENSFPP THFDTWERLS DYQKPSSSTT DDAYGKPVAK ISPTASIDER
     ETGIIGSTLR QDSTDSDSTG SSNMNPYDRL DKEVISKKNA HTNSYRNDVD ELEGSLRTLG
     LQKVNAPTIS SFSAWKSQSS ALPAPSSSET SKIVKAEIKA PQQPMSLNPN YFDVMREMEK
     SMNIFTKLFR GSQIRNKNDL PSGRHLVNYR QNHAFDFAAM SHIWKENKME NLPKLPHRAN
     LVMTLPSSRV RNSKICAFYR VLEKKEDKYI LVACHVNIHG FHRGDLRFVE VNNRTVLKGF
     ERSSVIGHLF LGDILTVTEL TRCNETVSNV ASSVEDASPD APCQWMASKV VLFPRHEPVN
     VQFKFTCNGM ASVVSTNEPM SVILNNLTEA KTNVEYTGIA FKSASYTVHT EDYTKKWYER
     IQEEISNIMI YPKALSTIYQ YEEYTPNFVV EKQEQEEHPY QQDLEDLDLY RQHEMQTNVF
     TKFFDIGKSE KRKFGPGKSI SNCRHSDAID FAAMSYIWKN IRQQHLPKLP KLPNMVLPLP
     TSMPLDSEIC AFYRVLVENK SKYILIACHM NVHGYHRGDL RFLEINESTK LYGFEGRSVI
     GQLFLGDIVA VTELARCNGH GSDAFKIPFD VSMSSQNTCT WMASKITLPS RPPPASVLFS
     FMKNRMAVVK GCDEPMNVEV KSIQNVEPDL IYKGTAFKPE KPELNFTEGF IKKKRHQIGS
     ITLRIASYPN SFGTIYNFQE SDIDNEHYKI GINAFSEEKF TEISLDEREK IVETCSLMGF
     SAANTIFNGR FDCRAFKMEE IKKNGMTVMF CIENPTSQPT LGLWCAGNRI VIGGPNGDVN
     GAIETVIDDP DIGYLRIAAR LSRDIPKKFS FKGDGEFFVS QREVFENEIL DDGYFKTLDP
     GCNGRRIIET LYGGKPLERV VVDKRDSSIE RMMSQLFGVG SGISEHKTSG KKSEDTPTQF
     YFPSTPEPLA LNKYQCEYVQ MLLDGNPLII GSSPFGCGKS MTIITAALEL YKLKKNRKQL
     LITQSNYASV NLIDIAQRVC LSGDDDLKDL KFVRFVSEKN WNELPSNCRT DSDMPYLMNK
     LFKDWAMGRI DLTNLTCLKT HHYVQMVSHI IKNDLVNPML FGDHIAQIYD KLSADFSRAP
     HAQTLVEAFF MIYKPDLVMV TADSAKGLLN ILRDVCAVQI DEASQLAECT LLGLLKSFNN
     ASFGLIGDIH QLPPYCEEGL EGKLKDFGIG NTMERAIKEK MFPVCTLRNV YRCHPKTTEL
     LSELFYDGAL VSGVSELARS DFMTKRDDFW PNPKFPMMFV NNTGASTKMG TSTSNSSEKS
     IVGEIVQNLI NDPRNPVNPS DIGVISFYSA QTSILTEHLR GSGVKCGTVD AFQGSEKEII
     IMCSTNERIS DFMQLSNRLN VAMSRAKQVT IIIGHLDGLR RANYWSTIVN KIEQNGNLVN
     ANDWYQNQRR NKVSLSSYPL ISTSRQSKQQ RANEYNSQHK HVKRQSNNDY GSQRSVTNSL
     NPEFVGKWDD ETYGDWPTIQ KST