ID   YQ13_SCHPO              Reviewed;         193 AA.
AC   O94520;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ER membrane protein complex subunit 4;
GN   ORFNames=SPCC1281.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the EMC4 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA22824.1; -; Genomic_DNA.
DR   PIR; T40922; T40922.
DR   RefSeq; NP_588167.1; NM_001023156.2.
DR   AlphaFoldDB; O94520; -.
DR   SMR; O94520; -.
DR   BioGRID; 275647; 5.
DR   STRING; 4896.SPCC1281.03c.1; -.
DR   iPTMnet; O94520; -.
DR   MaxQB; O94520; -.
DR   PaxDb; O94520; -.
DR   PRIDE; O94520; -.
DR   EnsemblFungi; SPCC1281.03c.1; SPCC1281.03c.1:pep; SPCC1281.03c.
DR   GeneID; 2539075; -.
DR   KEGG; spo:SPCC1281.03c; -.
DR   PomBase; SPCC1281.03c; -.
DR   VEuPathDB; FungiDB:SPCC1281.03c; -.
DR   eggNOG; KOG3318; Eukaryota.
DR   HOGENOM; CLU_098404_2_0_1; -.
DR   InParanoid; O94520; -.
DR   OMA; HASDWLD; -.
DR   PhylomeDB; O94520; -.
DR   PRO; PR:O94520; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0072546; C:EMC complex; ISO:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0045048; P:protein insertion into ER membrane; IC:PomBase.
DR   InterPro; IPR009445; TMEM85/Emc4.
DR   PANTHER; PTHR19315; PTHR19315; 1.
DR   Pfam; PF06417; DUF1077; 1.
DR   PIRSF; PIRSF017207; UCP017207_TM-p85; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..193
FT                   /note="ER membrane protein complex subunit 4"
FT                   /id="PRO_0000340089"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   193 AA;  21551 MW;  116FB8F9913CCE00 CRC64;
     MHINEETDWI DLVKPALAKK PKKIVDNSDK FPTPRGFQQK SLVSKNIHSG NSASSTSIFA
     KREEELQKDL LLKKAWELAY SPLKQIPMNA ILAYMSGNSL QIFSIMTTLM LLVNPLKAIT
     STGSAFTPFK GTHPGTLWPA MGAYILFQLL LMGIGVYKLQ RMGLLPTTTS DWLAWEVSKV
     FMDRSYGPSK TVL