ID   YQ4B_CAEEL              Reviewed;         577 AA.
AC   Q17426;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative pseudouridine synthase B0024.11;
DE            EC=5.4.99.-;
GN   ORFNames=B0024.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC         Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
CC       {ECO:0000305}.
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DR   EMBL; Z71178; CAA94883.1; -; Genomic_DNA.
DR   PIR; T18646; T18646.
DR   RefSeq; NP_505653.1; NM_073252.4.
DR   AlphaFoldDB; Q17426; -.
DR   SMR; Q17426; -.
DR   BioGRID; 44466; 4.
DR   IntAct; Q17426; 2.
DR   MINT; Q17426; -.
DR   STRING; 6239.B0024.11; -.
DR   iPTMnet; Q17426; -.
DR   EPD; Q17426; -.
DR   PaxDb; Q17426; -.
DR   PeptideAtlas; Q17426; -.
DR   EnsemblMetazoa; B0024.11.1; B0024.11.1; WBGene00007101.
DR   GeneID; 179436; -.
DR   KEGG; cel:CELE_B0024.11; -.
DR   UCSC; B0024.11; c. elegans.
DR   CTD; 179436; -.
DR   WormBase; B0024.11; CE05155; WBGene00007101; -.
DR   eggNOG; KOG2339; Eukaryota.
DR   GeneTree; ENSGT00530000063554; -.
DR   HOGENOM; CLU_005281_0_2_1; -.
DR   InParanoid; Q17426; -.
DR   OMA; CCETLPE; -.
DR   OrthoDB; 955294at2759; -.
DR   PhylomeDB; Q17426; -.
DR   PRO; PR:Q17426; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00007101; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2350.20; -; 2.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001656; PsdUridine_synth_TruD.
DR   InterPro; IPR020119; PsdUridine_synth_TruD_CS.
DR   InterPro; IPR011760; PsdUridine_synth_TruD_insert.
DR   InterPro; IPR042214; TruD_catalytic.
DR   PANTHER; PTHR13326; PTHR13326; 1.
DR   Pfam; PF01142; TruD; 1.
DR   PIRSF; PIRSF037016; Pseudouridin_synth_euk_prd; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00094; tRNA_TruD_broad; 1.
DR   PROSITE; PS50984; TRUD; 1.
DR   PROSITE; PS01268; UPF0024; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; tRNA processing.
FT   CHAIN           1..577
FT                   /note="Putative pseudouridine synthase B0024.11"
FT                   /id="PRO_0000152559"
FT   DOMAIN          265..472
FT                   /note="TRUD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00342"
FT   REGION          538..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..569
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        188
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   577 AA;  64631 MW;  A1F3BC06481CD281 CRC64;
     METEFGLTEY ASEHTITPVP CLLKEMYSDF IVQEILADHT VLAIPSPDVV LESTGSKKED
     IEIEECVAKP DCISEETLAA LNDRFSTKGD PVLVKVDDLS KEDRKSIHHF IRERYAGVLI
     TETKEDGILV SHGHTKSSRK RKLWDEKVPK ECHFTICKEN KETSFACQLI AKFLNVGPNN
     IRTHGIKDKR AVTSQRVSVT KVHERTILDL NSKLRGIRVF GCEYKDDPVQ MGAHWGNRFS
     IVLRSLPDDS EQLLHQRLET FQNTGFINYF GTQRFGSRSS TTAEIGLAIV KRDWEKAVKM
     IMTNAMPDHL GYGSVGYAAK CFSQTGDARK AFSKLKGAQA FATVEGNILK CLSKGGTWQN
     CITEAIPIQS RSLYVHAYQS LIWNKVASRR VKEYGTRVHE SDVGANGFSL GEHATHYDIH
     IPLPGENLPF EGSYGAKWIS ELLEEDGLTQ SSFTALKDRF SLGESSRCLF VEAKELKWKF
     IRYGNARDLL QDGLQTRAIP EAEQKGPLLA LQIQFSLISG SYATVALREV TGSDMGKKAM
     RDASFKTRGD DEKTEENVLE EKGSDDANEL NLVSEDQ