ID   YQ53_CAEEL              Reviewed;        1032 AA.
AC   Q09249;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized protein C16C10.3;
GN   ORFNames=C16C10.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; Z46787; CAA86741.1; -; Genomic_DNA.
DR   PIR; T19324; T19324.
DR   RefSeq; NP_497834.1; NM_065433.4.
DR   AlphaFoldDB; Q09249; -.
DR   SMR; Q09249; -.
DR   BioGRID; 40772; 31.
DR   IntAct; Q09249; 1.
DR   STRING; 6239.C16C10.3; -.
DR   EPD; Q09249; -.
DR   PaxDb; Q09249; -.
DR   PeptideAtlas; Q09249; -.
DR   EnsemblMetazoa; C16C10.3.1; C16C10.3.1; WBGene00007624.
DR   GeneID; 175535; -.
DR   KEGG; cel:CELE_C16C10.3; -.
DR   UCSC; C16C10.3; c. elegans.
DR   CTD; 175535; -.
DR   WormBase; C16C10.3; CE01494; WBGene00007624; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   GeneTree; ENSGT00970000196195; -.
DR   HOGENOM; CLU_012806_0_0_1; -.
DR   InParanoid; Q09249; -.
DR   OMA; LPHQMRE; -.
DR   OrthoDB; 540725at2759; -.
DR   PhylomeDB; Q09249; -.
DR   Reactome; R-CEL-203927; MicroRNA (miRNA) biogenesis.
DR   Reactome; R-CEL-426486; Small interfering RNA (siRNA) biogenesis.
DR   Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR   PRO; PR:Q09249; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007624; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0031332; C:RNAi effector complex; IDA:WormBase.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0035198; F:miRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; IMP:WormBase.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IMP:WormBase.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..1032
FT                   /note="Uncharacterized protein C16C10.3"
FT                   /id="PRO_0000065180"
FT   DOMAIN          369..481
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          650..977
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..335
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1032 AA;  117105 MW;  EBEAE23CE67BB149 CRC64;
     MADLLDKIMG SSSSNRIPKR DNRMNQDKDE PTSKRSAPMF STPKSTTPIG RDSFATMDTM
     NVQMNMFPVD IKDMPHKIQR FQVDVIVCSS NGKQINANLG VLAAKGDVNS HNRRLAQYYI
     MRTVHDKLLV KFSGKSHHFL AYDCAATLYL PEGVYTGDDQ EEVTLTIDDF PKEEWKFVSK
     LSRRKDDSYL VVLKPAGFVY TQGEVAQEEA NRMELTRIIE IVTSQKLNNE DYLQFGNATF
     PRLSPPHSEP DAISEIRSGF AKVSRLSQNG GGKAFMTVDT KISPFYKDTS VIKFSSNKLS
     EMKGGGGGRG GYGRSDSRDS RGGYRGGRSD SRDFRGVYGN RGGNDRYRDE SRGRRDMYDS
     RRDSGSSNGA DYSPSDAAEL EHAFGERGNT KRCIEEALKG LDVECTHLKG NLIRVSSIAE
     NNAENTSFMM KDDKGEREVT VAEYFLLQYN IKLKYPRLPL VVSKRFKHES FFPMELLRIA
     PGQRIKVNKM SPTVQSAMTG RNASMPQHHV KLVQDILRDN LKLEQNKYMD AFGIKLMSTE
     PIQMTAKLLP PAQIKFKGQT YMPDMSRPAF RTQDKFVEPA RIRKIGIVVF DNCIQMRQAE
     DFCDKLSNFC RDNGITVEKD SRDWSIRELN SSDSVAIQNL MKKWLDDRVD ILVGIAREKK
     PDVHDILKYF EESIGLQTIQ LCQQTVDKMM GGQGGRQTID NVMRKFNLKC GGTNFFVEIP
     NAVRGKAVCS NNETLRKKLL EHVQFIGFEI SHGASRTLFD RSRSQMDGEP SVVGVSYSLT
     NSTQLGGFTY LQTQKEYKLQ KLDEFFPKCV RSYKEHSKTL PTRIVIYRVG AGEGNFNRVK
     EEVEEMRRTF DKIQPGYRPH LVVIIAQRAS HARVFPSCIS GNRATDQNIP SGTCVENVLT
     SYGYDEFILS SQTPLIGTVR PCKYTILVND AKWSKNELMH LTYFRAFGHQ VSYQPPSVPD
     VLYAAENLAK RGRNNYKIHQ RYVNLQAVEN RIIKDHSELI NEDMREELAA AIVDEMSVAM
     NGMTIPKRNF WA