ID   CBPM_ECOLI              Reviewed;         101 AA.
AC   P63264; P36660;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Chaperone modulatory protein CbpM {ECO:0000255|HAMAP-Rule:MF_01155};
GN   Name=cbpM {ECO:0000255|HAMAP-Rule:MF_01155}; Synonyms=yccD;
GN   OrderedLocusNames=b0999, JW0984;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8302830; DOI=10.1073/pnas.91.3.1054;
RA   Ueguchi C., Kakeda M., Yamada H., Mizuno T.;
RT   "An analogue of the DnaJ molecular chaperone in Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:1054-1058(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   CHARACTERIZATION.
RC   STRAIN=K12 / DH5-alpha;
RX   PubMed=15184371; DOI=10.1074/jbc.m404862200;
RA   Chae C., Sharma S., Hoskins J.R., Wickner S.;
RT   "CbpA, a DnaJ homolog, is a DnaK co-chaperone, and its activity is
RT   modulated by CbpM.";
RL   J. Biol. Chem. 279:33147-33153(2004).
RN   [6]
RP   INHIBITION OF CBPA ACTIVITY.
RX   PubMed=17337578; DOI=10.1128/jb.01757-06;
RA   Chenoweth M.R., Trun N., Wickner S.;
RT   "In vivo modulation of a DnaJ homolog, CbpA, by CbpM.";
RL   J. Bacteriol. 189:3635-3638(2007).
CC   -!- FUNCTION: Interacts with CbpA and inhibits both the DnaJ-like co-
CC       chaperone activity and the DNA binding activity of CbpA. Together with
CC       CbpA, modulates the activity of the DnaK chaperone system. Does not
CC       inhibit the co-chaperone activity of DnaJ.
CC   -!- INDUCTION: In late stationary phase.
CC   -!- SIMILARITY: Belongs to the CbpM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01155}.
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DR   EMBL; D16500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U00096; AAC74084.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA36141.1; -; Genomic_DNA.
DR   PIR; E64841; E64841.
DR   RefSeq; NP_415519.1; NC_000913.3.
DR   RefSeq; WP_000024560.1; NZ_STEB01000006.1.
DR   AlphaFoldDB; P63264; -.
DR   SMR; P63264; -.
DR   BioGRID; 4262841; 8.
DR   DIP; DIP-47830N; -.
DR   IntAct; P63264; 1.
DR   STRING; 511145.b0999; -.
DR   jPOST; P63264; -.
DR   PaxDb; P63264; -.
DR   PRIDE; P63264; -.
DR   EnsemblBacteria; AAC74084; AAC74084; b0999.
DR   EnsemblBacteria; BAA36141; BAA36141; BAA36141.
DR   GeneID; 66670723; -.
DR   GeneID; 945597; -.
DR   KEGG; ecj:JW0984; -.
DR   KEGG; eco:b0999; -.
DR   PATRIC; fig|1411691.4.peg.1272; -.
DR   EchoBASE; EB2111; -.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_144710_3_1_6; -.
DR   OMA; YVIEIVE; -.
DR   PhylomeDB; P63264; -.
DR   BioCyc; EcoCyc:EG12194-MON; -.
DR   PRO; PR:P63264; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0004857; F:enzyme inhibitor activity; IDA:EcoCyc.
DR   HAMAP; MF_01155; CbpM; 1.
DR   InterPro; IPR022835; CbpM.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..101
FT                   /note="Chaperone modulatory protein CbpM"
FT                   /id="PRO_0000211627"
SQ   SEQUENCE   101 AA;  11512 MW;  387BBBBD577FDDB7 CRC64;
     MANVTVTFTI TEFCLHTGIS EEELNEIVGL GVVEPREIQE TTWVFDDHAA IVVQRAVRLR
     HELALDWPGI AVALTLMDDI AHLKQENRLL RQRLSRFVAH P