YQ92_SCHPO
ID YQ92_SCHPO Reviewed; 448 AA.
AC O74852;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized MFS-type transporter C18.02;
GN ORFNames=SPCC18.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA21416.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21416.1; -; Genomic_DNA.
DR PIR; T41145; T41145.
DR RefSeq; NP_588381.1; NM_001023372.2.
DR AlphaFoldDB; O74852; -.
DR SMR; O74852; -.
DR BioGRID; 275500; 4.
DR STRING; 4896.SPCC18.02.1; -.
DR iPTMnet; O74852; -.
DR PaxDb; O74852; -.
DR PRIDE; O74852; -.
DR EnsemblFungi; SPCC18.02.1; SPCC18.02.1:pep; SPCC18.02.
DR GeneID; 2538923; -.
DR KEGG; spo:SPCC18.02; -.
DR PomBase; SPCC18.02; -.
DR VEuPathDB; FungiDB:SPCC18.02; -.
DR eggNOG; KOG3764; Eukaryota.
DR HOGENOM; CLU_001265_51_3_1; -.
DR InParanoid; O74852; -.
DR OMA; FGWCVDR; -.
DR PhylomeDB; O74852; -.
DR Reactome; R-SPO-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-SPO-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-SPO-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-SPO-264642; Acetylcholine Neurotransmitter Release Cycle.
DR Reactome; R-SPO-442660; Na+/Cl- dependent neurotransmitter transporters.
DR Reactome; R-SPO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:O74852; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; ISM:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; ISM:PomBase.
DR GO; GO:0034220; P:ion transmembrane transport; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; ISM:PomBase.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..448
FT /note="Uncharacterized MFS-type transporter C18.02"
FT /id="PRO_0000372718"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 448 AA; 49057 MW; E4DA02AAA6C46EAC CRC64;
MGLKLWVKQR RSLPFIIGTI AIALFTDLFL YGIITPILPF SLVDRVGISP DRVQSVISTL
LAVYAVANIA ASSPIGFLAD KFLTRKVPML IGLIFLTSAT ALLTFGNSVP MLIVARVLQG
LSAAVVWTVG LALLVDVVGA DNVGSTMGGI FGFISLGEII APVFGGIVYE SLGYYASFGV
CFIILLLDIA LRFLMIEPRE MKNDSTLQDV ERTSILQRQD TQDHELKPKR SGLFSSLCLP
IYSLLHHKQI FGPFWTSFVN SCLFSAFDAT IPLELKTLFD FNSLQCGLMF GVLSTPYFFC
GAWAGAMVDR RGSRTIGKRA YAILGCTLFL LCIPRTNTSL NIYLFSAFLA INGVVLAFTS
SPGFVQSSHY VAEYELEHPT FFGHNGPYTQ LFSAYNIVYS LGMIIGPLVA GFLRDQFNFI
TSIACLSLLC FSASLMANSC FTDRLDSE
