YQC7_SCHPO
ID YQC7_SCHPO Reviewed; 133 AA.
AC O74469;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Exosome complex protein C1739.07;
GN ORFNames=SPCC1739.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP INTERACTION WITH CUT3.
RX PubMed=15148393; DOI=10.1073/pnas.0307976101;
RA Chen E.S., Sutani T., Yanagida M.;
RT "Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair
RT function of condensin.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:8078-8083(2004).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for exosome-dependent processing of pre-rRNA and
CC small nucleolar RNA (snRNA) precursors. Involved in processing of 35S
CC pre-rRNA at the A0, A1 and A2 sites (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the exosome multienzyme ribonuclease complex (By
CC similarity). Interacts with cut3. {ECO:0000250,
CC ECO:0000269|PubMed:15148393}.
CC -!- INTERACTION:
CC O74469; P41004: cut3; NbExp=3; IntAct=EBI-1149494, EBI-1149474;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the C1D family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20781.1; -; Genomic_DNA.
DR PIR; T41115; T41115.
DR RefSeq; NP_588415.1; NM_001023406.2.
DR AlphaFoldDB; O74469; -.
DR SMR; O74469; -.
DR BioGRID; 275677; 9.
DR IntAct; O74469; 3.
DR STRING; 4896.SPCC1739.07.1; -.
DR MaxQB; O74469; -.
DR PaxDb; O74469; -.
DR EnsemblFungi; SPCC1739.07.1; SPCC1739.07.1:pep; SPCC1739.07.
DR GeneID; 2539105; -.
DR KEGG; spo:SPCC1739.07; -.
DR PomBase; SPCC1739.07; -.
DR VEuPathDB; FungiDB:SPCC1739.07; -.
DR eggNOG; KOG4835; Eukaryota.
DR HOGENOM; CLU_064339_3_0_1; -.
DR InParanoid; O74469; -.
DR OMA; RIIKHHT; -.
DR PhylomeDB; O74469; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O74469; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000178; C:exosome (RNase complex); IDA:PomBase.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); ISO:PomBase.
DR GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:PomBase.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR GO; GO:0070651; P:nonfunctional rRNA decay; ISO:PomBase.
DR GO; GO:0071028; P:nuclear mRNA surveillance; TAS:PomBase.
DR GO; GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISO:PomBase.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISO:PomBase.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISO:PomBase.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0043144; P:sno(s)RNA processing; ISO:PomBase.
DR GO; GO:0016180; P:snRNA processing; ISO:PomBase.
DR InterPro; IPR011082; Exosome-assoc_fac/DNA_repair.
DR InterPro; IPR007146; Sas10/Utp3/C1D.
DR PANTHER; PTHR15341; PTHR15341; 1.
DR Pfam; PF04000; Sas10_Utp3; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW rRNA processing.
FT CHAIN 1..133
FT /note="Exosome complex protein C1739.07"
FT /id="PRO_0000339128"
FT REGION 96..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 133 AA; 15068 MW; DD333501508D60F1 CRC64;
MDPEYSELFE RLNKQLDNVE DVLKPLKDAE SIFELAEGKS ELEQAKLYIT MSYAINSTLY
SFYKLNGIDA SERPVMQELQ RVKNYISKIQ QAEKNVNPKT EAVNTSNAAI SSSSSNRPKV
AKDAATRIIK HHT
