YQCA_ECOLI
ID YQCA_ECOLI Reviewed; 149 AA.
AC P65367; Q2MA44; Q46917;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Flavodoxin YqcA {ECO:0000303|PubMed:23749454};
GN Name=yqcA; OrderedLocusNames=b2790, JW2761;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP COFACTOR, AND NMR STUDIES.
RX PubMed=23749454; DOI=10.1007/s12104-013-9498-y;
RA Ye Q., Hu Y., Jin C.;
RT "1H, 13C and 15N resonance assignments of the apo and holo states of
RT flavodoxin YqcA from Escherichia coli.";
RL Biomol. NMR. Assign. 8:269-273(2014).
RN [4] {ECO:0007744|PDB:2M6R, ECO:0007744|PDB:2M6S}
RP STRUCTURE BY NMR IN COMPLEX WITH AND WITHOUT FMN, COFACTOR, SUBUNIT, AND
RP DOMAIN.
RX PubMed=25093851; DOI=10.1371/journal.pone.0103936;
RA Ye Q., Hu Y., Jin C.;
RT "Conformational dynamics of Escherichia coli flavodoxins in apo- and holo-
RT states by solution NMR spectroscopy.";
RL PLoS ONE 9:e103936-e103936(2014).
CC -!- FUNCTION: Probable electron transporter.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000269|PubMed:23749454, ECO:0000269|PubMed:25093851};
CC Note=Binds 1 FMN non-covalently. {ECO:0000269|PubMed:23749454,
CC ECO:0000269|PubMed:25093851};
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:25093851}.
CC -!- DOMAIN: The structure is significantly stabilized upon cofactor
CC binding. {ECO:0000269|PubMed:25093851}.
CC -!- SIMILARITY: Belongs to the flavodoxin family. MioC subfamily.
CC {ECO:0000305}.
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DR EMBL; U29581; AAB40440.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75832.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76862.1; -; Genomic_DNA.
DR PIR; B65061; B65061.
DR RefSeq; NP_417270.1; NC_000913.3.
DR RefSeq; WP_000807753.1; NZ_LN832404.1.
DR PDB; 2M6R; NMR; -; A=1-149.
DR PDB; 2M6S; NMR; -; A=1-149.
DR PDBsum; 2M6R; -.
DR PDBsum; 2M6S; -.
DR AlphaFoldDB; P65367; -.
DR BMRB; P65367; -.
DR SMR; P65367; -.
DR BioGRID; 4261741; 23.
DR DIP; DIP-48153N; -.
DR IntAct; P65367; 6.
DR STRING; 511145.b2790; -.
DR jPOST; P65367; -.
DR PaxDb; P65367; -.
DR PRIDE; P65367; -.
DR EnsemblBacteria; AAC75832; AAC75832; b2790.
DR EnsemblBacteria; BAE76862; BAE76862; BAE76862.
DR GeneID; 66673343; -.
DR GeneID; 947151; -.
DR KEGG; ecj:JW2761; -.
DR KEGG; eco:b2790; -.
DR PATRIC; fig|1411691.4.peg.3943; -.
DR EchoBASE; EB2962; -.
DR eggNOG; COG0716; Bacteria.
DR HOGENOM; CLU_051402_4_1_6; -.
DR InParanoid; P65367; -.
DR OMA; SYDHFCG; -.
DR PhylomeDB; P65367; -.
DR BioCyc; EcoCyc:G7448-MON; -.
DR PRO; PR:P65367; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0010181; F:FMN binding; IDA:EcoCyc.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SUPFAM; SSF52218; SSF52218; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Flavoprotein; FMN; Nucleotide-binding;
KW Reference proteome; Transport.
FT CHAIN 1..149
FT /note="Flavodoxin YqcA"
FT /id="PRO_0000196577"
FT DOMAIN 4..145
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
FT BINDING 10..15
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0007744|PDB:2M6S"
FT BINDING 99..101
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0007744|PDB:2M6S"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:2M6R"
FT STRAND 11..13
FT /evidence="ECO:0007829|PDB:2M6S"
FT HELIX 18..29
FT /evidence="ECO:0007829|PDB:2M6R"
FT STRAND 32..38
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 41..44
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 45..47
FT /evidence="ECO:0007829|PDB:2M6R"
FT STRAND 50..56
FT /evidence="ECO:0007829|PDB:2M6R"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:2M6R"
FT TURN 66..68
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 69..78
FT /evidence="ECO:0007829|PDB:2M6R"
FT STRAND 86..93
FT /evidence="ECO:0007829|PDB:2M6R"
FT TURN 98..101
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 102..114
FT /evidence="ECO:0007829|PDB:2M6R"
FT STRAND 123..126
FT /evidence="ECO:0007829|PDB:2M6R"
FT TURN 127..129
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 134..144
FT /evidence="ECO:0007829|PDB:2M6R"
FT HELIX 145..147
FT /evidence="ECO:0007829|PDB:2M6R"
SQ SEQUENCE 149 AA; 16274 MW; 477B51ABB432999D CRC64;
MAEIGIFVGT MYGNSLLVAE EAEAILTAQG HKATVFEDPE LSDWLPYQDK YVLVVTSTTG
QGDLPDSIVP LFQGIKDSLG FQPNLRYGVI ALGDSSYVNF CNGGKQFDAL LQEQSAQRVG
EMLLIDASEN PEPETESNPW VEQWGTLLS
