YQEC_BACSU
ID YQEC_BACSU Reviewed; 297 AA.
AC P54448;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Putative 6-phosphogluconate dehydrogenase YqeC;
DE EC=1.1.1.-;
GN Name=yqeC; OrderedLocusNames=BSU25730;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP PROPOSED FUNCTION.
RX PubMed=15231785; DOI=10.1128/jb.186.14.4528-4534.2004;
RA Zamboni N., Fischer E., Laudert D., Aymerich S., Hohmann H.P., Sauer U.;
RT "The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate
RT dehydrogenase in the pentose phosphate pathway.";
RL J. Bacteriol. 186:4528-4534(2004).
CC -!- FUNCTION: May act as NAD-dependent 6-P-gluconate dehydrogenase.
CC -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; D84432; BAA12439.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14514.1; -; Genomic_DNA.
DR PIR; G69950; G69950.
DR RefSeq; NP_390450.1; NC_000964.3.
DR RefSeq; WP_003229961.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54448; -.
DR SMR; P54448; -.
DR STRING; 224308.BSU25730; -.
DR PaxDb; P54448; -.
DR PRIDE; P54448; -.
DR EnsemblBacteria; CAB14514; CAB14514; BSU_25730.
DR GeneID; 937809; -.
DR KEGG; bsu:BSU25730; -.
DR PATRIC; fig|224308.179.peg.2798; -.
DR eggNOG; COG1023; Bacteria.
DR InParanoid; P54448; -.
DR OMA; PYGYVHA; -.
DR PhylomeDB; P54448; -.
DR BioCyc; BSUB:BSU25730-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR Gene3D; 1.10.1040.10; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR004849; 6DGDH_YqeC.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006114; 6PGDH_C.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR006184; 6PGdom_BS.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006183; Pgluconate_DH.
DR PANTHER; PTHR11811; PTHR11811; 1.
DR Pfam; PF00393; 6PGD; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PRINTS; PR00076; 6PGDHDRGNASE.
DR SMART; SM01350; 6PGD; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR00872; gnd_rel; 1.
DR PROSITE; PS00461; 6PGD; 1.
PE 3: Inferred from homology;
KW Gluconate utilization; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..297
FT /note="Putative 6-phosphogluconate dehydrogenase YqeC"
FT /id="PRO_0000090077"
FT ACT_SITE 170
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 177
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 7..12
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 94
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 94
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 120..122
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 173..174
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 178
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 268
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 297 AA; 32769 MW; 83607681471AC73C CRC64;
MKIGLIGLGK MGINIGKQFI DRNHQVVGYD VNQAAVDELK AYGAEGTTNL KEFISLLHPP
RILWVMVPHG IVDAVLRDVS PLLSKGDMII EAGNSHYKES IRRYNQMKEA GIHYLDAGTS
GGMEGARHGA CFMVGGDHEA WEIVEPLFRD TAVENGYLYA GEAGSGHFLK MIHNGIEYGM
MAAIGEGFEV LENSQFDFDY EKVARVWNHG SVIRSWLMGL TERAFAKDAK LDQIKGIMHS
SGEGKWTVET ALDLQTATPV IAMSLMMRYR SLTDDTFTGK VVAALRNEFG GHATEKK
