YQEH_BACSU
ID YQEH_BACSU Reviewed; 366 AA.
AC P54453;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Uncharacterized protein YqeH;
GN Name=yqeH; OrderedLocusNames=BSU25670;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP GTP- AND GDP-BINDING, PROTEIN LEVELS, AND DISRUPTION PHENOTYPE.
RC STRAIN=CRK6000;
RX PubMed=12427945; DOI=10.1099/00221287-148-11-3539;
RA Morimoto T., Loh P.C., Hirai T., Asai K., Kobayashi K., Moriya S.,
RA Ogasawara N.;
RT "Six GTP-binding proteins of the Era/Obg family are essential for cell
RT growth in Bacillus subtilis.";
RL Microbiology 148:3539-3552(2002).
CC -!- FUNCTION: Binds GTP and GDP.
CC -!- DISRUPTION PHENOTYPE: Essential for growth, it cannot be disrupted. In
CC depletion experiments cells become 1.5 to 2-fold longer and nucleoid
CC distribution is dispersed. The number of replication origins increases,
CC suggesting an increase in chromosome replication.
CC {ECO:0000269|PubMed:12427945}.
CC -!- MISCELLANEOUS: Estimated to be present at 2000 copies per cell.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family.
CC {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR EMBL; D84432; BAA12444.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14509.1; -; Genomic_DNA.
DR PIR; D69951; D69951.
DR RefSeq; NP_390445.1; NC_000964.3.
DR RefSeq; WP_003229966.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54453; -.
DR SMR; P54453; -.
DR STRING; 224308.BSU25670; -.
DR jPOST; P54453; -.
DR PaxDb; P54453; -.
DR PRIDE; P54453; -.
DR EnsemblBacteria; CAB14509; CAB14509; BSU_25670.
DR GeneID; 937822; -.
DR KEGG; bsu:BSU25670; -.
DR PATRIC; fig|224308.179.peg.2790; -.
DR eggNOG; COG1161; Bacteria.
DR InParanoid; P54453; -.
DR OMA; HYNEVQD; -.
DR PhylomeDB; P54453; -.
DR BioCyc; BSUB:BSU25670-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IDA:CACAO.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR019988; GTP-bd_ribosome_bgen_YqeH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03597; GTPase_YqeH; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..366
FT /note="Uncharacterized protein YqeH"
FT /id="PRO_0000049785"
FT DOMAIN 59..222
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
SQ SEQUENCE 366 AA; 40999 MW; 6B2D47FA2FEEBA10 CRC64;
MEKVVCIGCG VTIQTEDKTG LGYAPPASLT KENVICQRCF RLKNYNEIQD VSLTDDDFLN
ILHGIGETDS LVVKIVDIFD FNGSWINGLQ RLVGGNPILL VGNKADILPK SLKRERLIQW
MKREAKELGL KPVDVFLVSA GRGQGIREVI DAIEHYRNGK DVYVVGCTNV GKSTFINRII
KEVSGEEDII TTSQFPGTTL DAIEIPLDDG SSLYDTPGII NNHQMAHYVN KKDLKILSPK
KELKPRTFQL NDQQTLYFGG LARFDYVSGE RSPFICYMPN ELMIHRTKLE NADALYEKHA
GELLTPPGKD EMDEFPELVA HTFTIKDKKT DIVFSGLGWV TVHDADKKVT AYAPKGVHVF
VRRSLI
