ID   YQFA_ECOLI              Reviewed;         219 AA.
AC   P67153; Q2M9U2; Q46827;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=UPF0073 inner membrane protein YqfA;
GN   Name=yqfA; OrderedLocusNames=b2899, JW2867;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the UPF0073 (Hly-III) family. {ECO:0000305}.
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DR   EMBL; U28375; AAA83080.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75937.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76964.1; -; Genomic_DNA.
DR   PIR; C65074; C65074.
DR   RefSeq; NP_417375.1; NC_000913.3.
DR   RefSeq; WP_000250274.1; NZ_STEB01000001.1.
DR   AlphaFoldDB; P67153; -.
DR   SMR; P67153; -.
DR   BioGRID; 4261705; 10.
DR   STRING; 511145.b2899; -.
DR   TCDB; 1.C.113.1.10; the hemolysin iii (hly iii) family.
DR   PaxDb; P67153; -.
DR   EnsemblBacteria; AAC75937; AAC75937; b2899.
DR   EnsemblBacteria; BAE76964; BAE76964; BAE76964.
DR   GeneID; 66673227; -.
DR   GeneID; 947381; -.
DR   KEGG; ecj:JW2867; -.
DR   KEGG; eco:b2899; -.
DR   PATRIC; fig|1411691.4.peg.3833; -.
DR   EchoBASE; EB2887; -.
DR   eggNOG; COG1272; Bacteria.
DR   HOGENOM; CLU_051078_1_0_6; -.
DR   InParanoid; P67153; -.
DR   OMA; HEVFHSL; -.
DR   PhylomeDB; P67153; -.
DR   BioCyc; EcoCyc:G7512-MON; -.
DR   PRO; PR:P67153; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR005744; Hy-lIII.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   TIGRFAMs; TIGR01065; hlyIII; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="UPF0073 inner membrane protein YqfA"
FT                   /id="PRO_0000176898"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..53
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..90
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..113
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..165
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..219
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  23847 MW;  F1D863D2D1A30DA0 CRC64;
     MVQKPLIKQG YSLAEEIANS VSHGIGLVFG IVGLVLLLVQ AVDLNASATA ITSYSLYGGS
     MILLFLASTL YHAIPHQRAK MWLKKFDHCA IYLLIAGTYT PFLLVGLDSP LARGLMIVIW
     SLALLGILFK LTIAHRFKIL SLVTYLAMGW LSLVVIYEMA VKLAAGSVTL LAVGGVVYSL
     GVIFYVCKRI PYNHAIWHGF VLGGSVCHFL AIYLYIGQA