YQG2_SCHPO
ID YQG2_SCHPO Reviewed; 640 AA.
AC O94419;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Putative GTPase-activating protein C1620.12c;
GN ORFNames=SPCC1620.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the GYP5 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22496.2; -; Genomic_DNA.
DR PIR; T41042; T41042.
DR RefSeq; NP_588470.2; NM_001023461.2.
DR AlphaFoldDB; O94419; -.
DR SMR; O94419; -.
DR BioGRID; 275446; 13.
DR STRING; 4896.SPCC1620.12c.1; -.
DR iPTMnet; O94419; -.
DR MaxQB; O94419; -.
DR PaxDb; O94419; -.
DR EnsemblFungi; SPCC1620.12c.1; SPCC1620.12c.1:pep; SPCC1620.12c.
DR PomBase; SPCC1620.12c; -.
DR VEuPathDB; FungiDB:SPCC1620.12c; -.
DR eggNOG; KOG1102; Eukaryota.
DR HOGENOM; CLU_427692_0_0_1; -.
DR InParanoid; O94419; -.
DR OMA; YLSYHET; -.
DR PRO; PR:O94419; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005798; C:Golgi-associated vesicle; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; ISO:PomBase.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0023052; P:signaling; IC:PomBase.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; GTPase activation; Nucleus; Reference proteome.
FT CHAIN 1..640
FT /note="Putative GTPase-activating protein C1620.12c"
FT /id="PRO_0000374036"
FT DOMAIN 215..408
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT REGION 96..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 500..636
FT /evidence="ECO:0000255"
FT COMPBIAS 99..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 72733 MW; A95E84C6899C6C82 CRC64;
MSKSVNASLS SAINSVTLVK QENLKENLQN GSAVSVGSSE SSNHSMKEIS LDYSSPSLQQ
TEEQDRELNF IDSSMLRPTP PQESDNRLAV EKPNIQPLQG HSPVPSFMST ASTNISSSKI
NNNQTEFEQL RDSYKSHGDL NSAINDSRIQ SIIFELNQQC EKESIPVSNI DWLQWASVPL
FAYDLPPDPS NPNATSSSPP PLTPILELIK QNNFCIPSPC RKLVWQSLVS AERNELLTLY
ATLSTTNNSL DSSIRKIIRM QSFRGPLEPF KYSSTTRHKV STESIFHVLH AFTLFDTTVE
YNIEPLLWLT CAFLSYMAQG NAFRSLVCFI QRGGIREFFI SQSSSLDESL FALVWGCLGD
LAPSVAISLQ RIKVSSLCIL YPSLACCFAD SLQLPEALRL MDLIAIYGLE MFVRLLVAIF
LKDRDKIVNM VSHEQWVKYL RSDVLASYRQ PLVQKYTFYT RTPVDLNAWV EDSLALNIDT
TQFPSYLSYH ETSVSHNTYR QNNLEELKNQ NDYLTSQITN LEEGMVMLNK ENTKLSEALS
NHRVTRSEME EATEILKNNS ADLKAQLEKQ PQELENRLLQ EISILKQRNQ KFLKNNATSI
QQIQYLDEEL GKTLKQLNDL KEKHAQLQTK WKSVSEMFRN
