CBPP_DICDI
ID CBPP_DICDI Reviewed; 467 AA.
AC P35085; Q54YX2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Calcium-binding protein P;
GN Name=cbpP; Synonyms=cbpA; ORFNames=DDB_G0277909;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX2;
RA Wennington R., Greenwood M., Tsang A.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; U03413; AAA03471.1; -; mRNA.
DR EMBL; AAFI02000023; EAL68127.1; -; Genomic_DNA.
DR RefSeq; XP_642080.1; XM_636988.1.
DR AlphaFoldDB; P35085; -.
DR PaxDb; P35085; -.
DR EnsemblProtists; EAL68127; EAL68127; DDB_G0277909.
DR GeneID; 8621293; -.
DR KEGG; ddi:DDB_G0277909; -.
DR dictyBase; DDB_G0277909; cbpP.
DR eggNOG; ENOG502SEZH; Eukaryota.
DR HOGENOM; CLU_585850_0_0_1; -.
DR InParanoid; P35085; -.
DR OMA; GAMPGAY; -.
DR PRO; PR:P35085; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..467
FT /note="Calcium-binding protein P"
FT /id="PRO_0000073850"
FT DOMAIN 399..434
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 435..467
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..49
FT /note="XYPPX"
FT MOTIF 75..79
FT /note="XYPPX"
FT MOTIF 83..87
FT /note="XYPPX"
FT MOTIF 94..98
FT /note="XYPPX"
FT MOTIF 104..108
FT /note="XYPPX"
FT MOTIF 115..119
FT /note="XYPPX"
FT MOTIF 125..129
FT /note="XYPPX"
FT MOTIF 136..140
FT /note="XYPPX"
FT MOTIF 146..150
FT /note="XYPPX"
FT MOTIF 157..161
FT /note="XYPPX"
FT MOTIF 165..169
FT /note="XYPPX"
FT MOTIF 176..180
FT /note="XYPPX"
FT MOTIF 187..191
FT /note="XYPPX"
FT MOTIF 221..225
FT /note="XYPPX"
FT MOTIF 238..242
FT /note="XYPPX"
FT MOTIF 247..251
FT /note="XYPPX"
FT MOTIF 256..260
FT /note="XYPPX"
FT MOTIF 275..279
FT /note="XYPPX"
FT COMPBIAS 41..114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 412
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 414
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 416
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 418
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 423
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT CONFLICT 182
FT /note="S -> P (in Ref. 1; AAA03471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 467 AA; 48966 MW; 09B15B310C443FE4 CRC64;
MQNPQNPPPA GSAADFYSQM PVKVMGTPGA PGSQSTPGAP GAPGQYPPQQ PGAPGSNLPP
YPGTQQPGAP GAPGQYPPQQ PGQYPPQQPG APGQYPPQQP GQPGYPPQQP GQSGQYPPQQ
PGQPGYPPQQ PGAPGQYPPQ QGQPGQYPPQ QPGQPGQYPP QQQGQYPPQQ PGQPGAYPPQ
QSGQPGAYPP QQGVQNTLAK TGAPGQPGVP PPQGAYPGQP GVPPQQGAYP GQQPPMGAYP
PQGQPGAYPP QGQPGAYPPQ QQQVAYPGQQ PPMGAYPPQQ GAYPGQQGAY PGQQGAYPGQ
QGAYPGQPPM GAYPGQQQYG VSAYSQTTAA YQTGAYPGQT PMGVYPGQTT AYAAYQTTAI
GYGATSTYSY TRPTYSYATP YSRTAAFVVP VGLPPHVVQK MMAASAAFRI HDSNCSGTLS
KKEFKKLIKH LGYYFSKGQT KMLFHSIDRD YSGSLSEREF VDWWSMQ
