ID   YQGF_STAA8              Reviewed;         142 AA.
AC   Q2FXW1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative pre-16S rRNA nuclease {ECO:0000255|HAMAP-Rule:MF_00651};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00651};
GN   OrderedLocusNames=SAOUHSC_01720;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=RN4220;
RX   PubMed=15044829; DOI=10.1159/000076741;
RA   Zalacain M., Biswas S., Ingraham K.A., Ambrad J., Bryant A., Chalker A.F.,
RA   Iordanescu S., Fan J., Fan F., Lunsford R.D., O'Dwyer K., Palmer L.M.,
RA   So C., Sylvester D., Volker C., Warren P., McDevitt D., Brown J.R.,
RA   Holmes D.J., Burnham M.K.;
RT   "A global approach to identify novel broad-spectrum antibacterial targets
RT   among proteins of unknown function.";
RL   J. Mol. Microbiol. Biotechnol. 6:109-126(2003).
CC   -!- FUNCTION: Could be a nuclease involved in processing of the 5'-end of
CC       pre-16S rRNA. {ECO:0000255|HAMAP-Rule:MF_00651}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00651}.
CC   -!- DISRUPTION PHENOTYPE: Not essential, it can be disrupted.
CC       {ECO:0000269|PubMed:15044829}.
CC   -!- SIMILARITY: Belongs to the YqgF nuclease family. {ECO:0000255|HAMAP-
CC       Rule:MF_00651}.
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DR   EMBL; CP000253; ABD30793.1; -; Genomic_DNA.
DR   RefSeq; WP_000939059.1; NZ_LS483365.1.
DR   RefSeq; YP_500229.1; NC_007795.1.
DR   AlphaFoldDB; Q2FXW1; -.
DR   SMR; Q2FXW1; -.
DR   STRING; 1280.SAXN108_1644; -.
DR   EnsemblBacteria; ABD30793; ABD30793; SAOUHSC_01720.
DR   GeneID; 3921070; -.
DR   KEGG; sao:SAOUHSC_01720; -.
DR   PATRIC; fig|93061.5.peg.1568; -.
DR   eggNOG; COG0816; Bacteria.
DR   HOGENOM; CLU_098240_2_0_9; -.
DR   OMA; PMGWTAQ; -.
DR   PRO; PR:Q2FXW1; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0000967; P:rRNA 5'-end processing; IBA:GO_Central.
DR   CDD; cd16964; YqgF; 1.
DR   Gene3D; 3.30.420.140; -; 1.
DR   HAMAP; MF_00651; Nuclease_YqgF; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR005227; YqgF.
DR   InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR   InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR   PANTHER; PTHR33317; PTHR33317; 1.
DR   Pfam; PF03652; RuvX; 1.
DR   SMART; SM00732; YqgFc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   TIGRFAMs; TIGR00250; RNAse_H_YqgF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Nuclease; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..142
FT                   /note="Putative pre-16S rRNA nuclease"
FT                   /id="PRO_0000257595"
SQ   SEQUENCE   142 AA;  15865 MW;  6ABFB72F24DB393D CRC64;
     MLQHKILGLD VGSRTVGIAI SDIMGWTAQG LDTLRINEEN NELGIDQLVD IIKKHNVGTV
     VIGLPKNMNN SIGFRGEASL TYKEKLLEAY PSIEIVMWDE RLSTMAAERS LLEADVSRQK
     RKQVIDKMAA VFILQGYLDS LH