ID   YQGF_STRR6              Reviewed;         139 AA.
AC   Q8DRE2;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Putative pre-16S rRNA nuclease {ECO:0000255|HAMAP-Rule:MF_00651};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00651};
GN   OrderedLocusNames=spr0176;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=15044829; DOI=10.1159/000076741;
RA   Zalacain M., Biswas S., Ingraham K.A., Ambrad J., Bryant A., Chalker A.F.,
RA   Iordanescu S., Fan J., Fan F., Lunsford R.D., O'Dwyer K., Palmer L.M.,
RA   So C., Sylvester D., Volker C., Warren P., McDevitt D., Brown J.R.,
RA   Holmes D.J., Burnham M.K.;
RT   "A global approach to identify novel broad-spectrum antibacterial targets
RT   among proteins of unknown function.";
RL   J. Mol. Microbiol. Biotechnol. 6:109-126(2003).
CC   -!- FUNCTION: Could be a nuclease involved in processing of the 5'-end of
CC       pre-16S rRNA. {ECO:0000255|HAMAP-Rule:MF_00651}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00651}.
CC   -!- DISRUPTION PHENOTYPE: Probably essential, it cannot be disrupted.
CC       {ECO:0000269|PubMed:15044829}.
CC   -!- SIMILARITY: Belongs to the YqgF nuclease family. {ECO:0000255|HAMAP-
CC       Rule:MF_00651}.
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DR   EMBL; AE007317; AAK98980.1; -; Genomic_DNA.
DR   PIR; H97893; H97893.
DR   RefSeq; NP_357770.1; NC_003098.1.
DR   RefSeq; WP_001808830.1; NC_003098.1.
DR   AlphaFoldDB; Q8DRE2; -.
DR   SMR; Q8DRE2; -.
DR   STRING; 171101.spr0176; -.
DR   EnsemblBacteria; AAK98980; AAK98980; spr0176.
DR   GeneID; 60233082; -.
DR   GeneID; 66805403; -.
DR   KEGG; spr:spr0176; -.
DR   PATRIC; fig|171101.6.peg.208; -.
DR   eggNOG; COG0816; Bacteria.
DR   HOGENOM; CLU_098240_2_0_9; -.
DR   OMA; PMGWTAQ; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0000967; P:rRNA 5'-end processing; IBA:GO_Central.
DR   CDD; cd16964; YqgF; 1.
DR   Gene3D; 3.30.420.140; -; 1.
DR   HAMAP; MF_00651; Nuclease_YqgF; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR005227; YqgF.
DR   InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR   InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR   PANTHER; PTHR33317; PTHR33317; 1.
DR   Pfam; PF03652; RuvX; 1.
DR   SMART; SM00732; YqgFc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   TIGRFAMs; TIGR00250; RNAse_H_YqgF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Nuclease; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..139
FT                   /note="Putative pre-16S rRNA nuclease"
FT                   /id="PRO_0000172150"
SQ   SEQUENCE   139 AA;  15655 MW;  597A484F224EC8BD CRC64;
     MRIMGLDVGS KTVGVAISDP LGFTAQGLEI IQINEEQGQF GFDRVKELVD TYKVERFVVG
     LPKNMNNTSG PRVEASQAYG AKLEEFFGLP VDYQDERLTT VAAERMLIEQ ADISRNKRKK
     VIDKLAAQLI LQNYLDRKF