YQGS_BACSU
ID YQGS_BACSU Reviewed; 638 AA.
AC P54496;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Lipoteichoic acid synthase-like YqgS;
DE Contains:
DE RecName: Full=Uncharacterized protein YqgS;
DE Contains:
DE RecName: Full=Processed uncharacterized protein YqgS;
GN Name=yqgS; OrderedLocusNames=BSU24840;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 7; 12; 301 AND 375.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP NON-INVOLVEMENT IN LTA BIOSYNTHESIS.
RC STRAIN=168;
RX PubMed=17483484; DOI=10.1073/pnas.0701821104;
RA Gruendling A., Schneewind O.;
RT "Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus
RT aureus.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8478-8483(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Processed uncharacterized protein YqgS]:
CC Secreted {ECO:0000250}.
CC -!- PTM: Proteolytically cleaved. {ECO:0000250}.
CC -!- MISCELLANEOUS: Although its sequence similarity with the glycerol
CC phosphate lipoteichoic acid synthase LtaS, it cannot restore
CC staphylococcal growth and LTA synthesis after ltaS depletion.
CC -!- SIMILARITY: Belongs to the LTA synthase family. {ECO:0000305}.
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DR EMBL; D84432; BAA12522.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14415.2; -; Genomic_DNA.
DR PIR; D69957; D69957.
DR RefSeq; NP_390364.2; NC_000964.3.
DR RefSeq; WP_004399146.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54496; -.
DR SMR; P54496; -.
DR STRING; 224308.BSU24840; -.
DR PaxDb; P54496; -.
DR PRIDE; P54496; -.
DR EnsemblBacteria; CAB14415; CAB14415; BSU_24840.
DR GeneID; 938209; -.
DR KEGG; bsu:BSU24840; -.
DR PATRIC; fig|224308.179.peg.2703; -.
DR eggNOG; COG1368; Bacteria.
DR InParanoid; P54496; -.
DR OMA; LSSWHFD; -.
DR PhylomeDB; P54496; -.
DR BioCyc; BSUB:BSU24840-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.720.10; -; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; SSF53649; 1.
PE 3: Inferred from homology;
KW Cell membrane; Manganese; Membrane; Metal-binding; Reference proteome;
KW Secreted; Transmembrane; Transmembrane helix.
FT CHAIN 1..215
FT /note="Uncharacterized protein YqgS"
FT /id="PRO_0000049814"
FT CHAIN 216..638
FT /note="Processed uncharacterized protein YqgS"
FT /id="PRO_0000305376"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ACT_SITE 295
FT /evidence="ECO:0000250"
FT BINDING 253
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 295
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 410
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 469
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 470
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT SITE 215..216
FT /note="Cleavage"
FT /evidence="ECO:0000250"
FT CONFLICT 7
FT /note="S -> P (in Ref. 1; BAA12522)"
FT /evidence="ECO:0000305"
FT CONFLICT 12
FT /note="M -> T (in Ref. 1; BAA12522)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="I -> N (in Ref. 1; BAA12522)"
FT /evidence="ECO:0000305"
FT CONFLICT 375
FT /note="S -> T (in Ref. 1; BAA12522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 638 AA; 73212 MW; 6CEDC0D558E2ED31 CRC64;
MRKTFFSKIS FMLIAILLMW LKTYAVYKTS FHIKIDNLTQ EFILFINPLS FLLLIFGLSL
FLKGKNRNRY IIAMSCLVTF VLLANMVFYR FYNDFLTIPV LFQTSNMGDL GSSIGTLLEP
TDLLLAVDIA VLIWLHIRQK AFQSDIPSTK NERAAYFLFV ASVYFFNLGL SEAERPQLLT
RSFDREMLVK NISLFNFHIY DGVLQSKQSA QRALADSNSL TEIENYVTAN AKDANKRLFG
AAKGRNVILV SLESTQSFVI NEKLNGEEIT PFLNDFIKQS YNFNNVYHQT GQGKTSDSEF
IVDNSLYPLG RGAVFFTNAG NQYMAAPEIL KNSGYYSAVL HANNKSFWNR DLMYDSFGYD
SFFDINSYDV TDENSVGWGL KDKEFFEQSS ELMKNLPQPF YSRLITLTNH FPFDLDEEDQ
LIDEYDSNSQ TLNKYFPTVR YQDEALKRFI EKLKEDGLYD NSVIVLYGDH YGISENHNEA
MGQFLGKEIT PFEEVQLQKV PLVIHIPGIT DKKPQTIETV GGQIDIRPTL MNLLGIDTKD
QIQFGNDLLS DEKLDFTVLR DGSFITDQVV YTDGACYDKE TGKPLEETKQ CEAFADKAKQ
ELSLSDEIIY GDLLRFYDQK RLDNSSKRKE KQMLDQAS
