ID   YQJI_ECOLI              Reviewed;         207 AA.
AC   P64588; Q2M9D5; Q46872;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Transcriptional regulator YqjI;
GN   Name=yqjI; OrderedLocusNames=b3071, JW3042;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR, DISRUPTION PHENOTYPE, ACTIVITY
RP   REGULATION, SUBUNIT, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=21097627; DOI=10.1128/jb.01062-10;
RA   Wang S., Wu Y., Outten F.W.;
RT   "Fur and the novel regulator YqjI control transcription of the ferric
RT   reductase gene yqjH in Escherichia coli.";
RL   J. Bacteriol. 193:563-574(2011).
CC   -!- FUNCTION: Represses the expression of YqjH which is involved in iron
CC       homeostasis under excess nickel conditions. Also represses its own
CC       expression. {ECO:0000269|PubMed:21097627}.
CC   -!- ACTIVITY REGULATION: Divalent metals such as nickel and iron have a
CC       similar negative effect on YqjI DNA-binding activity.
CC       {ECO:0000269|PubMed:21097627}.
CC   -!- SUBUNIT: Oligomer (probable predominant form) and monomer.
CC       {ECO:0000269|PubMed:21097627}.
CC   -!- INDUCTION: Autorepressed. {ECO:0000269|PubMed:21097627}.
CC   -!- DISRUPTION PHENOTYPE: Disruption leads to a 40-fold increase in yqjH
CC       basal expression. {ECO:0000269|PubMed:21097627}.
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DR   EMBL; U28379; AAA89150.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76106.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77121.1; -; Genomic_DNA.
DR   PIR; D65095; D65095.
DR   RefSeq; NP_417542.1; NC_000913.3.
DR   RefSeq; WP_000018003.1; NZ_STEB01000001.1.
DR   AlphaFoldDB; P64588; -.
DR   SMR; P64588; -.
DR   BioGRID; 4259594; 11.
DR   DIP; DIP-48127N; -.
DR   IntAct; P64588; 31.
DR   STRING; 511145.b3071; -.
DR   jPOST; P64588; -.
DR   PaxDb; P64588; -.
DR   PRIDE; P64588; -.
DR   EnsemblBacteria; AAC76106; AAC76106; b3071.
DR   EnsemblBacteria; BAE77121; BAE77121; BAE77121.
DR   GeneID; 58389425; -.
DR   GeneID; 947584; -.
DR   KEGG; ecj:JW3042; -.
DR   KEGG; eco:b3071; -.
DR   PATRIC; fig|1411691.4.peg.3659; -.
DR   EchoBASE; EB2788; -.
DR   eggNOG; COG1695; Bacteria.
DR   HOGENOM; CLU_063440_1_0_6; -.
DR   InParanoid; P64588; -.
DR   OMA; IADKPSH; -.
DR   PhylomeDB; P64588; -.
DR   BioCyc; EcoCyc:G7594-MON; -.
DR   PRO; PR:P64588; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR   GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005149; Tscrpt_reg_PadR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03551; PadR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulator YqjI"
FT                   /id="PRO_0000169438"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   207 AA;  23401 MW;  DD3D108D83E087F7 CRC64;
     MSHHHEGCCK HEGQPRHEGC CKGEKSEHEH CGHGHQHEHG QCCGGRHGRG GGRRQRFFGH
     GELRLVILDI LSRDDSHGYE LIKAIENLTQ GNYTPSPGVI YPTLDFLQEQ SLITIREEEG
     GKKQIALTEQ GAQWLEENRE QVEMIEERIK ARCVGAALRQ NPQMKRALDN FKAVLDLRVN
     QSDISDAQIK KIIAVIDRAA FDITQLD