YQZ2_CAEEL
ID YQZ2_CAEEL Reviewed; 482 AA.
AC Q09320; Q1W0S1; Q1W0S2; Q8ST16; Q8ST17;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Putative metallophosphoesterase F40B5.2;
DE EC=3.1.-.-;
GN ORFNames=F40B5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q09320-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q09320-2; Sequence=VSP_010626;
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC LOC643853 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CCD70883.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CCD70884.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; FO081340; CCD70883.1; ALT_SEQ; Genomic_DNA.
DR EMBL; FO081340; CCD70884.1; ALT_SEQ; Genomic_DNA.
DR PIR; T16303; T16303.
DR RefSeq; NP_509417.2; NM_077016.4.
DR RefSeq; NP_509418.2; NM_077017.2.
DR AlphaFoldDB; Q09320; -.
DR SMR; Q09320; -.
DR STRING; 6239.F40B5.2a; -.
DR EPD; Q09320; -.
DR PaxDb; Q09320; -.
DR PeptideAtlas; Q09320; -.
DR EnsemblMetazoa; F40B5.2a.1; F40B5.2a.1; WBGene00018226.
DR EnsemblMetazoa; F40B5.2b.1; F40B5.2b.1; WBGene00018226.
DR EnsemblMetazoa; F40B5.2b.2; F40B5.2b.2; WBGene00018226.
DR GeneID; 181090; -.
DR KEGG; cel:CELE_F40B5.2; -.
DR UCSC; F40B5.2b; c. elegans.
DR CTD; 181090; -.
DR WormBase; F40B5.2a; CE40055; WBGene00018226; -.
DR WormBase; F40B5.2b; CE40056; WBGene00018226; -.
DR eggNOG; ENOG502QRHG; Eukaryota.
DR GeneTree; ENSGT00390000010260; -.
DR InParanoid; Q09320; -.
DR OrthoDB; 1154756at2759; -.
DR PRO; PR:Q09320; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018226; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Hydrolase; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..482
FT /note="Putative metallophosphoesterase F40B5.2"
FT /id="PRO_0000065331"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 256
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 258
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 288
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 288
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 319
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 421
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 423
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT VAR_SEQ 78..104
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_010626"
SQ SEQUENCE 482 AA; 53488 MW; 61FEAED1599708E0 CRC64;
MSSRCKRCLN SFSEMNLKLK IAIIVIGFIH VSIAIARKST DGVAHHRLVR LHTILITSTA
MLSASYYIWK RVNFAITKLF KTLKSENELP IANSNESESD FAMNTLLPSP NPVGNRRLRL
ICFQDIAQAL MMLFLFLSHI AMFFYYIFLG PEPNVIAITS LSFIAAYAHI LIFLLIADVL
FYSTKLIHSK VAPNSVHTYL KENRCYHILL ALILGFIFMF AGLYTTHTDP IVRSASIPMK
RFQSNSGNVS IALLSDVHIG PSVGRTRIAK IVELTNALKP DIIAIAGDLA DGLVRDFHGA
AEPLCNLKAP GGVYFATGNH EYMHGNVTEW FWFLENCNIT VLHNLNKHIT VNGQKLCVAG
ADDLYALRSN VPGHGMDLRK ALGTCNSDST NILLAHQPNA AKIVLSDSEL SKKVNLILSG
HTHGGQMYPF VPIVHLANAF VRGQYYDKST DTYVYVSAGV NYFGPPIKMF GSCEIIFITM
TQ
