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YR135_MIMIV
ID   YR135_MIMIV             Reviewed;         702 AA.
AC   Q5UPL2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Putative GMC-type oxidoreductase R135;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MIMI_R135;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- INTERACTION:
CC       Q5UPL2; Q5UPL2: MIMI_R135; NbExp=2; IntAct=EBI-16157702, EBI-16157702;
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16971431}. Host
CC       membrane {ECO:0000269|PubMed:16971431}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:16971431}.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50410.1; -; Genomic_DNA.
DR   RefSeq; YP_003986627.1; NC_014649.1.
DR   PDB; 4Z24; X-ray; 2.00 A; A/B=51-702.
DR   PDB; 4Z25; X-ray; 3.34 A; A/B/C/D/E/F/G/H/I/J/K/L=51-702.
DR   PDB; 4Z26; X-ray; 2.92 A; A/B/C/D/E/F/G/H=51-702.
DR   PDBsum; 4Z24; -.
DR   PDBsum; 4Z25; -.
DR   PDBsum; 4Z26; -.
DR   SMR; Q5UPL2; -.
DR   DIP; DIP-61553N; -.
DR   GeneID; 9924735; -.
DR   KEGG; vg:9924735; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552; PTHR11552; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 2.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; FAD; Flavoprotein; Host membrane; Membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..702
FT                   /note="Putative GMC-type oxidoreductase R135"
FT                   /id="PRO_0000243955"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        628
FT                   /evidence="ECO:0000250"
FT   BINDING         58..88
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   STRAND          55..62
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           66..78
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          83..86
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          88..90
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           96..99
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           101..105
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            106..108
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           111..113
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           117..119
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            121..123
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          124..128
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            133..137
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          141..145
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           150..153
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           164..170
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           177..191
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           201..220
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           230..232
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          258..263
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          266..271
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          277..279
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           282..286
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            289..291
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          296..298
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           300..302
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          305..308
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          312..319
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          322..329
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          335..346
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            350..352
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           353..359
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           365..370
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            381..384
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          385..388
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          391..401
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           403..409
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            410..412
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            417..421
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          425..428
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            439..443
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          449..456
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           461..467
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          476..483
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          490..493
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          497..499
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          505..507
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           521..531
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           533..558
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          563..570
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           572..585
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           586..593
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           595..598
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           603..615
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           617..621
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          622..625
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   TURN            635..637
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   STRAND          643..645
FT                   /evidence="ECO:0007829|PDB:4Z25"
FT   STRAND          649..653
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           656..658
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           668..683
FT                   /evidence="ECO:0007829|PDB:4Z24"
FT   HELIX           687..690
FT                   /evidence="ECO:0007829|PDB:4Z24"
SQ   SEQUENCE   702 AA;  76947 MW;  E57AD7FE70F2292B CRC64;
     MKNKECCKCY NPCEKICVNY STTDVAFERP NPCKPIPCKP TPIPCDPCHN TKDNLTGDIV
     IIGAGAAGSL LAHYLARFSN MKIILLEAGH SHFNDPVVTD PMGFFGKYNP PNENISMSQN
     PSYSWQGAQE PNTGAYGNRP IIAHGMGFGG STMINRLNLV VGGRTVFDND WPVGWKYDDV
     KNYFRRVLVD INPVRDNTKA SITSVALDAL RIIAEQQIAS GEPVDFLLNK ATGNVPNVEK
     TTPDAVPLNL NDYEGVNSVV AFSSFYMGVN QLSDGNYIRK YAGNTYLNRN YVDENGRGIG
     KFSGLRVVSD AVVDRIIFKG NRAVGVNYID REGIMHYVKV NKEVVVTSGA FYTPTILQRS
     GIGDFTYLSS IGVKNLVYNN PLVGTGLKNH YSPVTITRVH GEPSEVSRFL SNMAANPTNM
     GFKGLAELGF HRLDPNKPAN ANTVTYRKYQ LMMTAGVGIP AEQQYLSGLS PSSNNLFTLI
     ADDIRFAPEG YIKIGTPNIP RDVPKIFFNT FVTYTPTSAP ADQQWPIAQK TLAPLISALL
     GYDIIYQTLM SMNQTARDSG FQVSLEMVYP LNDLIYKLHN GLATYGANWW HYFVPTLVGD
     DTPAGREFAD TLSKLSYYPR VGAHLDSHQG CSCSIGRTVD SNLKVIGTQN VRVADLSAAA
     FPPGGNTWAT ASMIGARAVD LILGFPYLRD LPVNDVPILN VN
 
 
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