ID   CBP_MESMA               Reviewed;          40 AA.
AC   P0C8M2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Serine proteinase-like BMK-CBP;
DE   Flags: Fragment;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=18625260; DOI=10.1016/j.toxicon.2008.06.003;
RA   Gao R., Zhang Y., Gopalakrishnakone P.;
RT   "Purification and N-terminal sequence of a serine proteinase-like protein
RT   (BMK-CBP) from the venom of the Chinese scorpion (Buthus martensii
RT   Karsch).";
RL   Toxicon 52:348-353(2008).
CC   -!- FUNCTION: Shows no significant hydrolytic activity. Binds in a dose-
CC       dependent manner to the cancer cell line MCF-7.
CC       {ECO:0000269|PubMed:18625260}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined MW is: 33 kDa.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00274}.
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DR   AlphaFoldDB; P0C8M2; -.
DR   SMR; P0C8M2; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IDA:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 2.40.10.10; -; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted.
FT   CHAIN           1..>40
FT                   /note="Serine proteinase-like BMK-CBP"
FT                   /id="PRO_0000359444"
FT   DOMAIN          1..>40
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   ACT_SITE        40
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
FT                   ECO:0000255|PROSITE-ProRule:PRU10078, ECO:0000255|PROSITE-
FT                   ProRule:PRU10079"
FT   NON_TER         40
SQ   SEQUENCE   40 AA;  4328 MW;  B5DB6682B54082F1 CRC64;
     IFGGTFAKNG EYPWMVVIDL PEFACGGVLI SKKFVLTAAH