CBP_SACER
ID CBP_SACER Reviewed; 177 AA.
AC P06495;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Calerythrin;
DE AltName: Full=Calcium-binding protein;
OS Saccharopolyspora erythraea (Streptomyces erythraeus).
OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC Saccharopolyspora.
OX NCBI_TaxID=1836;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3627246; DOI=10.1038/329084a0;
RA Swan D.G., Hale R.S., Dhillon N., Leadlay P.F.;
RT "A bacterial calcium-binding protein homologous to calmodulin.";
RL Nature 329:84-85(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2676983; DOI=10.1128/jb.171.10.5614-5619.1989;
RA Swan D.G., Cortes J., Hale R.S., Leadlay P.F.;
RT "Cloning, characterization, and heterologous expression of the
RT Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-
RT hand calcium-binding protein.";
RL J. Bacteriol. 171:5614-5619(1989).
CC -!- MISCELLANEOUS: This protein binds calcium.
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DR EMBL; M29700; AAA26481.1; -; Genomic_DNA.
DR PIR; A45916; A29289.
DR PDB; 1NYA; NMR; -; A=2-177.
DR PDBsum; 1NYA; -.
DR AlphaFoldDB; P06495; -.
DR BMRB; P06495; -.
DR SMR; P06495; -.
DR EvolutionaryTrace; P06495; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Metal-binding; Repeat.
FT CHAIN 1..177
FT /note="Calerythrin"
FT /id="PRO_0000073580"
FT DOMAIN 5..40
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 45..90
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 100..134
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 134..169
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 18
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 20
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 22
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 29
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 113
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 115
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 117
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 119
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 124
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 147
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 149
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 151
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 153
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 158
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT HELIX 5..16
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 23..25
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 28..40
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 48..68
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 78..89
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 94..111
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 118..121
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 122..131
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 136..146
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 151..155
FT /evidence="ECO:0007829|PDB:1NYA"
FT HELIX 156..163
FT /evidence="ECO:0007829|PDB:1NYA"
FT STRAND 167..169
FT /evidence="ECO:0007829|PDB:1NYA"
SQ SEQUENCE 177 AA; 19245 MW; A2FE8EDDC19405DC CRC64;
MTTAIASDRL KKRFDRWDFD GNGALERADF EKEAQHIAEA FGKDAGAAEV QTLKNAFGGL
FDYLAKEAGV GSDGSLTEEQ FIRVTENLIF EQGEASFNRV LGPVVKGTWG MCDKNADGQI
NADEFAAWLT ALGMSKAEAA EAFNQVDTNG NGELSLDELL TAVRDFHFGR LDVELLG
