ID   YR366_MIMIV             Reviewed;        1766 AA.
AC   Q5UR20;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative ATP-dependent RNA helicase R366;
DE            EC=3.6.4.13;
GN   OrderedLocusNames=MIMI_R366;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50635.1; -; Genomic_DNA.
DR   SMR; Q5UR20; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1766
FT                   /note="Putative ATP-dependent RNA helicase R366"
FT                   /id="PRO_0000253410"
FT   DOMAIN          656..865
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          947..1116
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          209..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           812..815
FT                   /note="DEAH box"
FT   BINDING         669..676
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1766 AA;  208526 MW;  BEF9AEC76D0479C3 CRC64;
     MALNTLINNN SWDILPKWIE YNDEHYKFLS RELINVVFPI LRETDKQLLL DSIILVINMI
     HFKFGFGSID KPDELLWHQL IQNNLLDSRA ILNAMLPYIN DNAKDDKKHR LRNLEDLYLE
     KDDRGQYVYT NSQYNRCIRR LETDGKISVF NRPCIREYFL DHLEILLMSI ETSANKLYVN
     WVDVLPVKMS DFDTLDIYKQ TVVKLNSYKS SSNQNSNQSN QESNESNQEP NESNQEINQE
     SNRNTFNRID LINNYIDPNS GLSYQDIYNT ISNHLFHEIK NYKWLIYDIV IAEKPVSYLK
     YLENKFDFDE LLEGRMWSQL DKSQTIRFQN QWNSFLNSSD TNDNTVLHHF YFFFSKYHKN
     SQKLIRQNKL VLNKDPDDEE DIEENVRITP ETTQDARRGM SQVPIEEIYL FFSDQLTSFK
     KTWYFYTIQI NKKEYVDSED NIIITPKNIY NYCKSLVSYT NASGKFTQIP KYWYSLKPEF
     IEMILIRILD INDPIKNDWT KNNWFNINNY IRKFYPDTKE EDLPVMNYKL HSLIRNNIVD
     IIFESLIFHG ILSNFKPNLT ITDNSYIRAS IGSTDDNKRT KFKHQQMAKQ YFTGKTRTEY
     ETNAYYYLTG QTYDQLKPLR NKTYHNFEKK YFDFLTSEQI WTFTYAMNWV SQLNFYHHYS
     NNRVLYITGA TGVGKSTQVP KLLMYSQKML DYNSNGKIIC TQPRVPPTVE NADTISRELG
     VPIRAYNKLY DKSVFTSNFY VQYKHQKEEH IDRQADYFLR IVTDGTLLEE MIGSPFLTRS
     IEDPYAVDNL GNQLDWVKTY STGNVYDIVI VDEAHEHNAN MDMILTLARD SIYVNNSTKL
     VIVSATMDDD EPIYRRYYRR INDNRTYPLS AFIDYNQLDR ANMDRRIHIS PPGATTQYVI
     RDFYLTDEES ALINEKNFID YGIKKTIELA NSTTNGDILL FMTGQADIHK SIKAINAATP
     PNIVALGYYS ELSEETKELI VKIHQTLASY TRYKEDVELD ESEITRRVPK GTYTRAIIIA
     TNVAEASITL KNLKYVVDTG YNKVVVYDPI DGVYDTWTLP ISFSSAMQRR GRVGRLSSGD
     FYALYSLNKV INNKTAYKIA DINIKDTMVK LIKSYPNDPF IISPMNDINQ ISNLVSIVNK
     RLTNNYVPED LIYDILNNPR PYYDIINKQY LYIPDLTDIS QYYTYYGKSS DIVLDEFDPN
     KINLSDYLRT NHDDYHFQQN HGAFYSRCYT GYDNYILEDQ SLTFYIIHPD ENIINRNLYT
     GQMDSLKIAS SIKESYYYYL LKVNNIQEKS DLQRINFRNF QLIKYPLAMS EAELQMLIMN
     VPAKKSDLVI RYTNIVDSNI NSYTEEYYSG LPNVNINDMT RVKSLLLINL GQIQSAVSLN
     ILNNYNNILW YSYAIPYQLN HDVLAIMVMI DLASDINQWI DPSKSRCCLN KFLNQHFNKE
     GDIKFLWDLW KKIQPILIKN NLLNTNDINY LRSDFNRNKE KYLSEKKIPF NEFLLFDKLF
     NSGKLNTTDE FYYYVNGINF DFVMENNNVS RMIEILSENE LLNKDKIIDF VSQYLSLNFT
     IYKQMWSHQY EIENKLNENS DNNKDIVEWV DKNLRFPNII THPYNMPDDW DKILETYIRA
     LSTNVVKNQG SYYLKMNNGV KIFPSRWSRF NPTEKTFLNN KSEFIIYHSN DSTDNKVNIM
     YLTPVQLKWI LDANPIYYYY LIFDKNNIIN KLKETDNIKE ILQTISSVKP YYSIKSLIEY
     VDRMNNPTIS RLIRSEIYGL DNSTKN