ID   YR419_MIMIV             Reviewed;         342 AA.
AC   Q5UQM3;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Uncharacterized short-chain type dehydrogenase/reductase R419;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MIMI_R419;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50688.1; -; Genomic_DNA.
DR   RefSeq; YP_003986923.1; NC_014649.1.
DR   SMR; Q5UQM3; -.
DR   GeneID; 9925040; -.
DR   KEGG; vg:9925040; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..342
FT                   /note="Uncharacterized short-chain type
FT                   dehydrogenase/reductase R419"
FT                   /id="PRO_0000054892"
FT   ACT_SITE        222
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         9..31
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   342 AA;  37872 MW;  9FBEA33220880C59 CRC64;
     MRFSDSVVLI FGGTTGIGLM TTIDFIIHNT SHIILASRSK WKWKRAIEKI QNIFGDLVNL
     SNEFNISVLN STVEYIPCDI RIENDVKQTI QKTIDKYHYI NVYFNNAGIQ PTTGHTDGDI
     TEIEIPSEKL FDGTIVYKIS QNNSNNDNLN NDNSNNDNSS VCSTPASSYC ENPIATFIMG
     MTFCLKHEVK FALEQKSNIP VSIINMSSRN GVNIPSSDRP IYSACKAFIH SMTQTIATQS
     AKLGIEKNRS IRVNCIAPGP ILTPLEIPIF LPDKKNVFEP LSNLELQQFQ EIGSHGVPMK
     RTGTTNEISP TVLFLADYNQ SSYITGSTIT IDGGYTASPL IG