ID   YR528_MIMIV             Reviewed;         621 AA.
AC   Q5UQ94;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Putative 5'-3' exonuclease R528;
DE            EC=3.1.11.-;
GN   OrderedLocusNames=MIMI_R528;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16971431}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50792.1; -; Genomic_DNA.
DR   PRIDE; Q5UQ94; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016070; P:RNA metabolic process; IEA:UniProt.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR004859; Put_53exo.
DR   InterPro; IPR041412; Xrn1_helical.
DR   PANTHER; PTHR12341; PTHR12341; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
PE   1: Evidence at protein level;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome; Virion.
FT   CHAIN           1..621
FT                   /note="Putative 5'-3' exonuclease R528"
FT                   /id="PRO_0000248965"
SQ   SEQUENCE   621 AA;  74127 MW;  82D98CD2B4E8D24C CRC64;
     MSEEYKKRIL IQYENYLLQQ DNYVYLATKN SVNWSRNKIT PGTAFMNKLV NYLKSDQIQS
     LLNTNRQDMN IIITDMYEVG EGEKKIVNYV HKYLHNTSDT VMVYSPDADV ILLCMLMPVS
     NLYMLRHNQE TSKKFKRNIY DLINIKMLKN NISYYINNNP DFSRENFIVD NINYDLVCIS
     TLFGNDFVPK IETINVKKGF QNIMDAYLKT LIELKERNTY LVRKVNGKFN LSLTFLRRVI
     KNLLPEENDY IKHNKLYNTY VTAGQIKNVF SYMEINSENI VSVYNEFMRE YGDLKNLIKN
     NGNLTYFETN DQFMNSLKKS ICIIMDDQCV NTSYLSNKDT IKLLRNYYIK TREFPRVNIN
     LNTWSHSTDD RRHRNIIREN NYNKYQIEIY KFDKMLDEYY VKFNAQPLDL SRNKIEQFYE
     TYFGIILLDK NKNLTEEANE IMRDYTEGLL WVFDYYFNDK TYVNRWYYQH EKAPLLTHLS
     MYLDGINHDY FNDLLSGLKK YRVKNIKNFF NPVEQLIYVS PMIPGIIKLL PSNYRSYITS
     DHLDPFLKTY FIDVEEIVDQ LWDQKISDEI DCRSIPYLNK CIIKSIEKPS SSEDKLFLTA
     IRKVKPTATS HKRSKSIEPD F