ID   YR568_MIMIV             Reviewed;         695 AA.
AC   Q5UR49;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Putative ATP-dependent DNA helicase R568;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=MIMI_R568;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: ATP-dependent DNA helicase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50831.1; -; Genomic_DNA.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11070; PTHR11070; 3.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..695
FT                   /note="Putative ATP-dependent DNA helicase R568"
FT                   /id="PRO_0000247399"
FT   DOMAIN          86..499
FT                   /note="UvrD-like helicase ATP-binding"
FT   BINDING         107..114
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   695 AA;  81912 MW;  4D3B5D7C00B1831F CRC64;
     MSLVPKAGYP FIIYFLDNIN KYISDKTIQT YLTAFQINVD NLKVINKQFI PEAYRIIKLF
     TTNTTIMFAI YNYIFHGISK IGFLEKFSEE QIKYITDLET TDTKLIACAG SGKTRSVIGR
     IKFMVEHGLA DKDEIYAITF SKHAATDFHR RIRELFPDYE NFCQLKNFST IDSMAKSILC
     RVKHHRSENV EILSIALRNF LKEATDEEIN SITKFKIIKH LFIDEAQDLN NIQFDIALMF
     KKHFGTTIHL CGDPNQNIYQ FRRSSNSYLM EFPAKKFELT LNFRSTQEII DFSECLKPIA
     TTRSVSGTNK IGPKVTIMTK QAIQIHKLIL YFLKQYEKKN DLSNIAIICP TRGTGVNANT
     GLAMIFNFLK SNHIKVNQLY CESSSDERKR LVDRIPGHIN LLTYHGTKGL EFDTVFVMDF
     YHSLLNIEPT YEEHNINQYL LYVATSRAIS KMFICTYINN YGGYLNHWIT KVDPKYYLID
     SQPKIHKLTF RNEEIFDSNG VTELLEKLSE EDLYSIYELI KVNTFYEKRI FPDHTDIDRG
     KDEALYGIFC EELFYLCYYL NKKLEPRRFE LIEKIVKSKF IIVENDLECN ILKKFINTNN
     LTWTQFDQNK NNFRKDVIKL VEKYFSRNVE LNDSIICTND FINIVEANKI DIRDTYNRYL
     QPDKYQYNYN NIIFDLFYLV VVQYAYDINH YIYIK