ID   CBRA_ECOLI              Reviewed;         354 AA.
AC   P31456; Q2M802;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Protein CbrA;
DE   AltName: Full=CreB-regulated gene A protein;
GN   Name=cbrA; Synonyms=yidS; OrderedLocusNames=b3690, JW5631;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA   Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT   "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT   organizational symmetry around the origin of replication.";
RL   Genomics 16:551-561(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   INDUCTION BY AI-2.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=11514505; DOI=10.1128/jb.183.18.5239-5247.2001;
RA   DeLisa M.P., Wu C.-F., Wang L., Valdes J.J., Bentley W.E.;
RT   "DNA microarray-based identification of genes controlled by autoinducer 2-
RT   stimulated quorum sensing in Escherichia coli.";
RL   J. Bacteriol. 183:5239-5247(2001).
RN   [5]
RP   INDUCTION BY CREBC.
RX   PubMed=11350954; DOI=10.1074/jbc.m011186200;
RA   Avison M.B., Horton R.E., Walsh T.R., Bennett P.M.;
RT   "Escherichia coli CreBC is a global regulator of gene expression that
RT   responds to growth in minimal media.";
RL   J. Biol. Chem. 276:26955-26961(2001).
RN   [6]
RP   MUTANT STUDIES.
RX   PubMed=12897016; DOI=10.1128/jb.185.16.4956-4972.2003;
RA   Zhou L., Lei X.-H., Bochner B.R., Wanner B.L.;
RT   "Phenotype microarray analysis of Escherichia coli K-12 mutants with
RT   deletions of all two-component systems.";
RL   J. Bacteriol. 185:4956-4972(2003).
CC   -!- INDUCTION: Induced by the two-component regulatory system CreC/CreB and
CC       by the signal autoinducer AI-2. {ECO:0000269|PubMed:11350954,
CC       ECO:0000269|PubMed:11514505}.
CC   -!- MISCELLANEOUS: Disruption of this gene leads to greater resistance to
CC       hydroxylamine and hypersensitivity to ofloxacin, 5,7-dichloro-8-
CC       hydroxyquinaldine (a lipophilic chelator) and 18-crown-6 ether (an
CC       ionophore).
CC   -!- SIMILARITY: Belongs to the CbrA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA62042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L10328; AAA62042.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76713.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77604.1; -; Genomic_DNA.
DR   PIR; C65171; C65171.
DR   RefSeq; NP_418145.2; NC_000913.3.
DR   RefSeq; WP_001340434.1; NZ_SSZK01000035.1.
DR   AlphaFoldDB; P31456; -.
DR   SMR; P31456; -.
DR   BioGRID; 4261311; 15.
DR   DIP; DIP-12455N; -.
DR   IntAct; P31456; 1.
DR   STRING; 511145.b3690; -.
DR   PaxDb; P31456; -.
DR   PRIDE; P31456; -.
DR   EnsemblBacteria; AAC76713; AAC76713; b3690.
DR   EnsemblBacteria; BAE77604; BAE77604; BAE77604.
DR   GeneID; 948197; -.
DR   KEGG; ecj:JW5631; -.
DR   KEGG; eco:b3690; -.
DR   PATRIC; fig|511145.12.peg.3813; -.
DR   EchoBASE; EB1665; -.
DR   eggNOG; COG0644; Bacteria.
DR   HOGENOM; CLU_024648_1_0_6; -.
DR   InParanoid; P31456; -.
DR   OMA; TYMSIQQ; -.
DR   PhylomeDB; P31456; -.
DR   BioCyc; EcoCyc:EG11714-MON; -.
DR   PRO; PR:P31456; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IDA:EcoCyc.
DR   GO; GO:0030153; P:bacteriocin immunity; IMP:EcoCyc.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..354
FT                   /note="Protein CbrA"
FT                   /id="PRO_0000013929"
SQ   SEQUENCE   354 AA;  40142 MW;  3A58C8A91F7B65FB CRC64;
     MEHFDVAIIG LGPAGSALAR KLAGKMQVIA LDKKHQCGTE GFSKPCGGLL APDAQRSFIR
     DGLTLPVDVI ANPQIFSVKT VDVAASLTRN YQRSYININR HAFDLWMKSL IPASVEVYHD
     SLCRKIWRED DKWHVIFRAD GWEQHITARY LVGADGANSM VRRHLYPDHQ IRKYVAIQQW
     FAEKHPVPFY SCIFDNSITN CYSWSISKDG YFIFGGAYPM KDGQTRFTTL KEKMSAFQFQ
     FGKTVKSEKC TVLFPSRWQD FVCGKDNAFL IGEAAGFISA SSLEGISYAL DSTDILRSVL
     LKQPEKLNTA YWRATRKLRL KLFGKIVKSR CLTAPALRKW IMRSGVAHIP QLKD