YRA2_ASHGO
ID YRA2_ASHGO Reviewed; 196 AA.
AC Q755R9;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=RNA annealing protein YRA2;
GN Name=YRA2; OrderedLocusNames=AER449W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in export of poly(A) mRNAs from the nucleus.
CC Recruited to the coding sequences as well as poly-A sites of active
CC genes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with mRNPs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YRA1 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS53128.2; -; Genomic_DNA.
DR RefSeq; NP_985304.2; NM_210658.2.
DR AlphaFoldDB; Q755R9; -.
DR SMR; Q755R9; -.
DR STRING; 33169.AAS53128; -.
DR EnsemblFungi; AAS53128; AAS53128; AGOS_AER449W.
DR GeneID; 4621525; -.
DR KEGG; ago:AGOS_AER449W; -.
DR eggNOG; ENOG502S444; Eukaryota.
DR HOGENOM; CLU_111217_0_0_1; -.
DR InParanoid; Q755R9; -.
DR OMA; KQTAQEH; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR CDD; cd12295; RRM_YRA2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025715; FoP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034396; Yra2_RRM.
DR Pfam; PF13865; FoP_duplication; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 3: Inferred from homology;
KW DNA-binding; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW Transport.
FT CHAIN 1..196
FT /note="RNA annealing protein YRA2"
FT /id="PRO_0000409540"
FT DOMAIN 63..137
FT /note="RRM"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22713 MW; 47ACE5069DD72952 CRC64;
MSVDEHLNQG TGEKQYRRRD LRNGLASRMG LGESTYRARE YGPSRRSRFR DRRDARPPPP
THQRVRFLNI PLDVSDYEID DLLKDLPKPL YSKFYDHEDS RSAVFEFEDH SILDKCVELY
NGLELHGAKI TVEIFEQQGR FADSTRTNRS TDHVEKEAGF KTGRPRGKAR ATKKEKPPQP
TLEDLDAELD AYMNGN
