ID   YRB1_ENCCU              Reviewed;         219 AA.
AC   Q8SSI6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Ran-specific GTPase-activating protein 1;
DE   AltName: Full=Ran-binding protein 1;
DE            Short=RANBP1;
GN   Name=YRB1; OrderedLocusNames=ECU02_0140;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL
RP   STAGE, AND SUBCELLULAR LOCATION.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Important for the export of protein containing nuclear export
CC       signal (NES) out of the nucleus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shuttles between the nucleus and cytoplasm. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the RANBP1 family. {ECO:0000305}.
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DR   EMBL; AL590442; CAD25045.1; -; Genomic_DNA.
DR   RefSeq; NP_584541.1; NM_001040730.1.
DR   AlphaFoldDB; Q8SSI6; -.
DR   SMR; Q8SSI6; -.
DR   STRING; 284813.Q8SSI6; -.
DR   PRIDE; Q8SSI6; -.
DR   GeneID; 858531; -.
DR   KEGG; ecu:ECU02_0140; -.
DR   VEuPathDB; MicrosporidiaDB:ECU02_0140; -.
DR   HOGENOM; CLU_104726_0_0_1; -.
DR   InParanoid; Q8SSI6; -.
DR   OMA; CANHLLM; -.
DR   OrthoDB; 1298372at2759; -.
DR   Proteomes; UP000000819; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000156; Ran_bind_dom.
DR   InterPro; IPR045255; RanBP1-like.
DR   PANTHER; PTHR23138; PTHR23138; 1.
DR   Pfam; PF00638; Ran_BP1; 1.
DR   SMART; SM00160; RanBD; 1.
DR   PROSITE; PS50196; RANBD1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; GTPase activation; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..219
FT                   /note="Ran-specific GTPase-activating protein 1"
FT                   /id="PRO_0000382911"
FT   DOMAIN          70..210
FT                   /note="RanBD1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  25077 MW;  6CD3A57F650254F5 CRC64;
     MAEVERKEEQ AKIESGSNEQ KERGLDGVNK GDAVGDGKEG GEAKKVQQSP FLTNAVPRKD
     EGKGGEERDN IDAAEVVEKQ RKHLEENQSD EILFKARCKL YYFSEETKAL EERAEGTMII
     EMHSKSNLAK ITMFRDQIGR LGCNHFINPR FKAQPHGKVS NGWMWMSTED TVETDALRKK
     IQLFVVKFYS EEDFKRFGEE YDLGRAHNEK ALKTKTNKK