YRBG_ECOLI
ID YRBG_ECOLI Reviewed; 325 AA.
AC P45394; Q2M916;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Inner membrane protein YrbG;
GN Name=yrbG; OrderedLocusNames=b3196, JW3163;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000305}.
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DR EMBL; U18997; AAA57997.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76228.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77240.1; -; Genomic_DNA.
DR PIR; F65110; F65110.
DR RefSeq; NP_417663.1; NC_000913.3.
DR RefSeq; WP_000922901.1; NZ_LN832404.1.
DR AlphaFoldDB; P45394; -.
DR SMR; P45394; -.
DR BioGRID; 4261579; 6.
DR STRING; 511145.b3196; -.
DR TCDB; 2.A.19.5.1; the ca(2+):cation antiporter (caca) family.
DR PaxDb; P45394; -.
DR EnsemblBacteria; AAC76228; AAC76228; b3196.
DR EnsemblBacteria; BAE77240; BAE77240; BAE77240.
DR GeneID; 947730; -.
DR KEGG; ecj:JW3163; -.
DR KEGG; eco:b3196; -.
DR PATRIC; fig|1411691.4.peg.3535; -.
DR EchoBASE; EB2654; -.
DR eggNOG; COG0530; Bacteria.
DR HOGENOM; CLU_007948_0_2_6; -.
DR InParanoid; P45394; -.
DR OMA; TRDYGVM; -.
DR PhylomeDB; P45394; -.
DR BioCyc; EcoCyc:YRBG-MON; -.
DR PRO; PR:P45394; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:EcoliWiki.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 1.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR10846; PTHR10846; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR TIGRFAMs; TIGR00367; TIGR00367; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Inner membrane protein YrbG"
FT /id="PRO_0000209507"
FT TOPO_DOM 1..5
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..67
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..198
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..269
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..325
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 325 AA; 34741 MW; BC08E0BBFD56A6C3 CRC64;
MLLATALLIV GLLLVVYSAD RLVFAASILC RTFGIPPLII GMTVVSIGTS LPEVIVSLAA
SLHEQRDLAV GTALGSNIIN ILLILGLAAL VRPFTVHSDV LRRELPLMLL VSVVAGSVLY
DGQLSRSDGI FLLFLAVLWL LFIVKLARQA ERQGTDSLTR EQLAELPRDG GLPVAFLWLG
IALIIMPVAT RMVVDNATVL ANYFAISELT MGLTAIAIGT SLPELATAIA GVRKGENDIA
VGNIIGANIF NIVIVLGLPA LITPGEIDPL AYSRDYSVML LVSIIFALLC WRRSPQPGRG
VGVLLTGGFI VWLAMLYWLS PILVE
