YRKA_BACSU
ID YRKA_BACSU Reviewed; 434 AA.
AC P54428; O07087;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=UPF0053 protein YrkA;
GN Name=yrkA; OrderedLocusNames=BSU26610;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA Duesterhoeft A., Ehrlich S.D.;
RT "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT operon reveals two new extracytoplasmic function RNA polymerase sigma
RT factors SigV and SigZ.";
RL Microbiology 143:2939-2943(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 218-434.
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 261-434.
RC STRAIN=168 / BD170;
RX PubMed=7608059; DOI=10.1128/jb.177.14.3904-3910.1995;
RA Ahmed M., Lyass L., Markham P.N., Taylor S.S., Vazquez-Laslop N.,
RA Neyfakh A.A.;
RT "Two highly similar multidrug transporters of Bacillus subtilis whose
RT expression is differentially regulated.";
RL J. Bacteriol. 177:3904-3910(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR EMBL; U93876; AAB80911.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14602.1; -; Genomic_DNA.
DR EMBL; D84432; BAA12353.1; -; Genomic_DNA.
DR EMBL; L32599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; G69975; G69975.
DR RefSeq; NP_390538.1; NC_000964.3.
DR RefSeq; WP_003246022.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54428; -.
DR SMR; P54428; -.
DR STRING; 224308.BSU26610; -.
DR TCDB; 1.A.112.2.2; the cyclin m mg2+ exporter (cnnm) family.
DR PaxDb; P54428; -.
DR PRIDE; P54428; -.
DR DNASU; 937634; -.
DR EnsemblBacteria; CAB14602; CAB14602; BSU_26610.
DR GeneID; 937634; -.
DR KEGG; bsu:BSU26610; -.
DR PATRIC; fig|224308.179.peg.2891; -.
DR eggNOG; COG1253; Bacteria.
DR InParanoid; P54428; -.
DR OMA; FMIMTYL; -.
DR PhylomeDB; P54428; -.
DR BioCyc; BSUB:BSU26610-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF01595; DUF21; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..434
FT /note="UPF0053 protein YrkA"
FT /id="PRO_0000088373"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..201
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT DOMAIN 220..282
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 289..346
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT CONFLICT 218..225
FT /note="EIMIPRRE -> VDLQVNGS (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="L -> W (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="T -> P (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="V -> G (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="Q -> R (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 434 AA; 48985 MW; F63296CB37043B3D CRC64;
MTTINLIIFT LLIVLTAFFV ATEFAIVKIR SSKIDQLILE GKKGAISAKK VITHLDEYLS
ACQLGITVTA LGIGWVGEST FEVILHPLFA HFHVSETVSH VLILVIAFVM ATFLHVVVGE
LAPKTLAIQK AETITLLTAK PIIWFYRILF PFIWFLNGSA RFIVGLFGLK PASEHELAHS
EEELRILLSE SYKSGEINQN ELKYVNNIFE FDERIAKEIM IPRREIVAIS SEDSYETIVK
IIKTESYTRY PVLNGDKDSI IGFINAKEFL SAYIDTDQKI KEDFKLENHI NPVIHVIESV
PIHDVLVKMQ KERTHIAILV DEYGGTSGLV TAEDILEEIV GEIRDEFDKD EVPNIRKVND
NHYILDSKVL IEDVNDLLGT TLASDEVDTI GGWFMTQQID AAVGSVIEAD GYIFKVHETV
GRHINYLEIV RKKE
