ID   YRKH_BACSU              Reviewed;         377 AA.
AC   P54435;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Uncharacterized protein YrkH;
GN   Name=yrkH; OrderedLocusNames=BSU26510;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA12363.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D84432; BAA12363.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB14592.2; -; Genomic_DNA.
DR   PIR; F69976; F69976.
DR   RefSeq; NP_390528.2; NC_000964.3.
DR   RefSeq; WP_009967833.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P54435; -.
DR   SMR; P54435; -.
DR   STRING; 224308.BSU26510; -.
DR   PaxDb; P54435; -.
DR   PRIDE; P54435; -.
DR   EnsemblBacteria; CAB14592; CAB14592; BSU_26510.
DR   GeneID; 937656; -.
DR   KEGG; bsu:BSU26510; -.
DR   PATRIC; fig|224308.179.peg.2879; -.
DR   eggNOG; COG0491; Bacteria.
DR   eggNOG; COG0607; Bacteria.
DR   InParanoid; P54435; -.
DR   OMA; AHFMIID; -.
DR   PhylomeDB; P54435; -.
DR   BioCyc; BSUB:BSU26510-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0050313; F:sulfur dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR   GO; GO:0070813; P:hydrogen sulfide metabolic process; IBA:GO_Central.
DR   CDD; cd07724; POD-like_MBL-fold; 1.
DR   Gene3D; 3.40.250.10; -; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR044528; POD-like_MBL-fold.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..377
FT                   /note="Uncharacterized protein YrkH"
FT                   /id="PRO_0000049873"
FT   DOMAIN          19..114
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   ACT_SITE        75
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
SQ   SEQUENCE   377 AA;  42400 MW;  A830110E6023DAC6 CRC64;
     MKHDRKGNDP KRSDKKIFNK EPLFILDVRN ENDFSDWKIE GHDFDHLNVP YFDLLDGVED
     ILEKIPSDKE VLVVCAKEGS SVMVSEMLSE AGHSVSYLKG GMKAWSEHLE PVKVGDLKDG
     GEMYQFVRIG KGCLSYMVIS NGEAAIIDAT RMVNFFIDFA KGKGATITHV FDTHLHADHI
     SGGRVIAEKT KATYWLPPKD AEEVEFDYQP LEEGNDIIIG NTTIKIQPIY SPGHTIGSTS
     FIVDDQYLLS GDILFIDSIG RPDLAGMAED WVGDLRKTLY SRYKALSKDL IVLPAHFMII
     DELNENGSVG KQLSTLFSEN HGLNIADETE FRHLVTDHLP PQPNAYQEIR ETNMGKISPD
     EEKQREMEIG PNRCAIR