YRM1_YEAST
ID YRM1_YEAST Reviewed; 786 AA.
AC Q12340; D6W2M8; E9PAH0; Q6B2M3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger transcription factor YRM1;
DE AltName: Full=Reveromycin resistance modulator 1;
GN Name=YRM1; OrderedLocusNames=YOR172W; ORFNames=O3620;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972579;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1563::aid-yea44>3.0.co;2-m;
RA Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P.;
RT "Analysis of a 22,956 bp region on the right arm of Saccharomyces
RT cerevisiae chromosome XV.";
RL Yeast 12:1563-1573(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION.
RX PubMed=14512416; DOI=10.1074/jbc.m309580200;
RA Lucau-Danila A., Delaveau T., Lelandais G., Devaux F., Jacq C.;
RT "Competitive promoter occupancy by two yeast paralogous transcription
RT factors controlling the multidrug resistance phenomenon.";
RL J. Biol. Chem. 278:52641-52650(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP FUNCTION.
RX PubMed=15145054; DOI=10.1016/j.gene.2004.02.003;
RA Onda M., Ota K., Chiba T., Sakaki Y., Ito T.;
RT "Analysis of gene network regulating yeast multidrug resistance by
RT artificial activation of transcription factors: involvement of Pdr3 in salt
RT tolerance.";
RL Gene 332:51-59(2004).
CC -!- FUNCTION: Transcription factor involved in the regulation of multidrug
CC resistance genes. Acts in concert with YRR1.
CC {ECO:0000269|PubMed:14512416, ECO:0000269|PubMed:15145054}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U55021; AAB47417.1; -; Genomic_DNA.
DR EMBL; Z75080; CAA99380.1; -; Genomic_DNA.
DR EMBL; Z75081; CAA99382.1; -; Genomic_DNA.
DR EMBL; AY692707; AAT92726.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10944.1; -; Genomic_DNA.
DR PIR; S67060; S67060.
DR RefSeq; NP_014815.3; NM_001183591.3.
DR AlphaFoldDB; Q12340; -.
DR BioGRID; 34566; 38.
DR DIP; DIP-4118N; -.
DR IntAct; Q12340; 1.
DR MINT; Q12340; -.
DR STRING; 4932.YOR172W; -.
DR iPTMnet; Q12340; -.
DR PaxDb; Q12340; -.
DR PRIDE; Q12340; -.
DR EnsemblFungi; YOR172W_mRNA; YOR172W; YOR172W.
DR GeneID; 854343; -.
DR KEGG; sce:YOR172W; -.
DR SGD; S000005698; YRM1.
DR VEuPathDB; FungiDB:YOR172W; -.
DR eggNOG; ENOG502SJDI; Eukaryota.
DR GeneTree; ENSGT00940000176356; -.
DR HOGENOM; CLU_010594_0_0_1; -.
DR InParanoid; Q12340; -.
DR OMA; LENLWVW; -.
DR BioCyc; YEAST:G3O-33685-MON; -.
DR PRO; PR:Q12340; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12340; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:SGD.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..786
FT /note="Zinc finger transcription factor YRM1"
FT /id="PRO_0000269650"
FT DNA_BIND 31..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 158
FT /note="K -> Q (in Ref. 4; AAT92726)"
FT /evidence="ECO:0000305"
FT CONFLICT 604
FT /note="D -> G (in Ref. 4; AAT92726)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 786 AA; 91084 MW; 3096ABD7AAF9B553 CRC64;
MSKRGSLQDR ASPSEETVKK AQKRRKPIKS CAFCRKRKLR CDQQKPMCST CKTRGRSGCL
YTEKFTHKIE TKELFGSTPN IELLKRIEDL EKRLDDKELT EKDVALSTSP FRNPYANFYY
LQCKGSGRRI VYGPTSLRTH LSNDDNRFVN TYNQLWSKVK IERNRWKARH KWTMKPETQL
LEGPPLEKTG SDILQQVCNV LPSFEQSSKI ITDFFNTELE TNEVSEVLDK TKIINDFTSS
FLPSDELLPN GERRIEKLLP STKKNYYKIG VILMILCIRH FYKNTPEEIE KFLIMLTGLS
TAKVYFIERA QFLLLKYYHR ELIWACGDDS HMISLVDLLC STAIMLGLHL NIREIYKNQE
NIVGSMESLE NLWVWIILSD FNVSLNIGRC LAINSSYFQV DECENGERLP KNTNNYSSTV
FFDQSNSCMG KLKRFLRLAR PMLDQIYDRS AFPDLAENCK KLRNFVETEF HPISYYTDSE
LISKVPLCEI KVLAQVLNLL LTFYSLRYLI YKEKSVVLEN NILQTILVSF SLVINTTILC
FNLDEKHFPE FFDHNCVHLP PFMALSLVYT NFLFPRASTG FCAFLYHKLT LFEKGYYLSS
NIKDQEVTDW DLSTLNIPLD KAMNLLTAFK IHSDIFAKWS NDNNKQLRII MARSYTFVIN
IALESIYRAV LEKVIKYRTE VENTWLQQLQ DELNGSYSLT DNVNTPIDPS LSDLGVTSAS
PLAGNSPGLP PEEVRNNSEN ASHNNETGPI ETELAQTISN EFWTAYNLGW EELMSQPDYK
YLFDTQ
