ID   YRPG_BACSU              Reviewed;         326 AA.
AC   O05408; Q796A0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized oxidoreductase YrpG;
DE            EC=1.-.-.-;
GN   Name=yrpG; OrderedLocusNames=BSU26850;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA   Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA   Duesterhoeft A., Ehrlich S.D.;
RT   "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT   operon reveals two new extracytoplasmic function RNA polymerase sigma
RT   factors SigV and SigZ.";
RL   Microbiology 143:2939-2943(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB80886.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U93875; AAB80886.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB14626.2; -; Genomic_DNA.
DR   PIR; F69978; F69978.
DR   RefSeq; NP_390562.2; NC_000964.3.
DR   RefSeq; WP_004398762.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O05408; -.
DR   SMR; O05408; -.
DR   STRING; 224308.BSU26850; -.
DR   PaxDb; O05408; -.
DR   PRIDE; O05408; -.
DR   EnsemblBacteria; CAB14626; CAB14626; BSU_26850.
DR   GeneID; 937611; -.
DR   KEGG; bsu:BSU26850; -.
DR   PATRIC; fig|224308.179.peg.2917; -.
DR   eggNOG; COG0667; Bacteria.
DR   InParanoid; O05408; -.
DR   OMA; HIELYQM; -.
DR   PhylomeDB; O05408; -.
DR   BioCyc; BSUB:BSU26850-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   Coiled coil; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Uncharacterized oxidoreductase YrpG"
FT                   /id="PRO_0000360676"
FT   COILED          242..305
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        53
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         215..225
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  36630 MW;  075BCEE2730633BD CRC64;
     MEYTYLGRTG LRVSRLCLGT MNFGVDTDEK TAFRIMDEAL DNGIQFFDTA NIYGWGKNAG
     LTESIIGKWF AQGGQRREKV VLATKVYEPI SDPNDGPNDM RGLSLYKIRR HLEGSLKRLQ
     TDHIELYQMH HIDRRTPWDE IWEAFETQVR SGKVDYIGSS NFAGWHLVKA QAEAEKRRFM
     GLVTEQHKYS LLERTAEMEV LPAARDLGLG VVAWSPLAGG LLGGKALKSN AGTRTAKRAD
     LIEKHRLQLE KFSDLCKELG EKEANVALAW VLANPVLTAP IIGPRTVEQL RDTIKAVEIS
     LDKEILRMLN DIFPGPGGET PEAYAW