YRR1_YEAST
ID YRR1_YEAST Reviewed; 810 AA.
AC Q12172; D6W2M0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger transcription factor YRR1;
DE AltName: Full=Pleiotropic drug-resistance protein 2;
GN Name=YRR1; Synonyms=PDR2; OrderedLocusNames=YOR162C; ORFNames=O3571;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972579;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1563::aid-yea44>3.0.co;2-m;
RA Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P.;
RT "Analysis of a 22,956 bp region on the right arm of Saccharomyces
RT cerevisiae chromosome XV.";
RL Yeast 12:1563-1573(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION.
RX PubMed=9767597; DOI=10.1046/j.1365-2958.1998.01027.x;
RA Cui Z., Shiraki T., Hirata D., Miyakawa T.;
RT "Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-
RT oxide, mediates transcriptional activation of the multidrug resistance
RT transporter gene SNQ2.";
RL Mol. Microbiol. 29:1307-1315(1998).
RN [6]
RP FUNCTION.
RX PubMed=10052137; DOI=10.1271/bbb.63.162;
RA Cui Z., Hirata D., Miyakawa T.;
RT "Functional analysis of the promoter of the yeast SNQ2 gene encoding a
RT multidrug resistance transporter that confers the resistance to 4-
RT nitroquinoline N-oxide.";
RL Biosci. Biotechnol. Biochem. 63:162-167(1999).
RN [7]
RP FUNCTION.
RX PubMed=11909958; DOI=10.1128/mcb.22.8.2642-2649.2002;
RA Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C.;
RT "New insights into the pleiotropic drug resistance network from genome-wide
RT characterization of the YRR1 transcription factor regulation system.";
RL Mol. Cell. Biol. 22:2642-2649(2002).
RN [8]
RP FUNCTION.
RX PubMed=14512416; DOI=10.1074/jbc.m309580200;
RA Lucau-Danila A., Delaveau T., Lelandais G., Devaux F., Jacq C.;
RT "Competitive promoter occupancy by two yeast paralogous transcription
RT factors controlling the multidrug resistance phenomenon.";
RL J. Biol. Chem. 278:52641-52650(2003).
RN [9]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [10]
RP FUNCTION.
RX PubMed=15145054; DOI=10.1016/j.gene.2004.02.003;
RA Onda M., Ota K., Chiba T., Sakaki Y., Ito T.;
RT "Analysis of gene network regulating yeast multidrug resistance by
RT artificial activation of transcription factors: involvement of Pdr3 in salt
RT tolerance.";
RL Gene 332:51-59(2004).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Transcription factor involved in the regulation of multidrug
CC resistance genes. Acts in concert with YRR1.
CC {ECO:0000269|PubMed:10052137, ECO:0000269|PubMed:11909958,
CC ECO:0000269|PubMed:14512416, ECO:0000269|PubMed:15145054,
CC ECO:0000269|PubMed:9767597}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
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DR EMBL; U55021; AAB47409.1; -; Genomic_DNA.
DR EMBL; Z75070; CAA99368.1; -; Genomic_DNA.
DR EMBL; AY692760; AAT92779.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10936.1; -; Genomic_DNA.
DR PIR; S67050; S67050.
DR RefSeq; NP_014805.3; NM_001183581.3.
DR AlphaFoldDB; Q12172; -.
DR SMR; Q12172; -.
DR BioGRID; 34558; 40.
DR DIP; DIP-5493N; -.
DR IntAct; Q12172; 5.
DR MINT; Q12172; -.
DR STRING; 4932.YOR162C; -.
DR iPTMnet; Q12172; -.
DR MaxQB; Q12172; -.
DR PaxDb; Q12172; -.
DR PRIDE; Q12172; -.
DR EnsemblFungi; YOR162C_mRNA; YOR162C; YOR162C.
DR GeneID; 854333; -.
DR KEGG; sce:YOR162C; -.
DR SGD; S000005688; YRR1.
DR VEuPathDB; FungiDB:YOR162C; -.
DR eggNOG; ENOG502SJDI; Eukaryota.
DR GeneTree; ENSGT00940000176356; -.
DR HOGENOM; CLU_010594_0_0_1; -.
DR InParanoid; Q12172; -.
DR OMA; YNSGWEE; -.
DR BioCyc; YEAST:G3O-33679-MON; -.
DR PRO; PR:Q12172; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12172; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IDA:SGD.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..810
FT /note="Zinc finger transcription factor YRR1"
FT /id="PRO_0000269651"
FT DNA_BIND 54..82
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 92468 MW; 1B4A32A91CFF2515 CRC64;
MKRRSDALLG SFQATNVTPP SDNSNSTAGG ANGSNSGTPT STSGKKRNKL IKSCGFCRRR
KLRCDQQKPM CSTCISRNLT TCQYAEEFNK NIEKKATYGP YPNADLLKKV EELENKIRIL
EAEKNTNSSA SSMYTSPNFP PLGTSVGRGS TETSSPLPDG VINPYADRYY LQSKHSGRST
LYGPTSMRTQ IANSNWGFIE KYKQLWAKVK VERNKWKQNN QKTMCRELGL LDESDWQPDP
LIKQICRFLP SYNKALSILD DFFNDGACNE INVILDKAKV RRDFLDYFMP EKEVKAEGDR
SIVYILSNPK KNYYKAAVIL LILCLKYFHT DVPTPIEKFF TLLKGASTAK VFYIERAQML
ILFYYHRETY SFGGDGSDLV NINECLVTTV TTIGLHLNIR ETFKEHEVFM GSIESLENVW
LMAIFIDYNI SCNVGRPLLI NKFYLDENQD HCILNSKSKT YEGKLKRYLK LTRPMLLTLY
DRDKFPDLKA YSKRIINFVE EELGPLGHYT GENISEEVPL RESRILSMAV GLLLSFYALI
HSVLKVRNIE SKNNTFQLVL INFSIIVNTT IRCYRIDKAL YPEKFEASNP HLPPHMALSM
SLTAGLFSKT LVFFCSLIYF KLTLFENGLC LSNDMEVGWS DLTKLTVPLD KDLSLGTAMS
LYSSIFDRLF TVGNKELIRT MHRSSQFVIE LAIERTYRTI LGNVIEFRKL TEETWLAQIK
QELDPQSDNP SSEAKIVSDR QRDLSLAVPT PTPSIIPMLP SPGETKNHAK SQSEIIQMLT
DEFWANYNSG WEELINQSEF STLFDDYKDN
