YS1_MAIZE
ID YS1_MAIZE Reviewed; 682 AA.
AC Q9AY27;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Iron-phytosiderophore transporter yellow stripe 1;
DE AltName: Full=ZmYS1;
GN Name=YS1;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=11201743; DOI=10.1038/35053080;
RA Curie C., Panaviene Z., Loulergue C., Dellaporta S.L., Briat J.-F.,
RA Walker E.L.;
RT "Maize yellow stripe1 encodes a membrane protein directly involved in
RT Fe(III) uptake.";
RL Nature 409:346-349(2001).
RN [2]
RP FUNCTION, AND INHIBITION BY CCCP.
RX PubMed=14699112; DOI=10.1074/jbc.m311799200;
RA Schaaf G., Ludewig U., Erenoglu B.E., Mori S., Kitahara T., von Wiren N.;
RT "ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and
RT nicotianamine-chelated metals.";
RL J. Biol. Chem. 279:9091-9096(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15107503; DOI=10.1104/pp.103.037572;
RA Roberts L.A., Pierson A.J., Panaviene Z., Walker E.L.;
RT "Yellow stripe1. Expanded roles for the maize iron-phytosiderophore
RT transporter.";
RL Plant Physiol. 135:112-120(2004).
CC -!- FUNCTION: Involved in Fe(3+) uptake. Acts as a proton-coupled symporter
CC for phytosiderophore- and nicotianamine-chelated metals. Capable of
CC transporting either Fe(2+)-nicotianamine or Fe(3+)-phytosiderophore.
CC May transport iron, zinc, nickel, copper and, at a lower rate,
CC manganese and cadmium. {ECO:0000269|PubMed:11201743,
CC ECO:0000269|PubMed:14699112, ECO:0000269|PubMed:15107503}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots of young maize seedlings. Not
CC detected in leaves of iron-sufficient plants, but accumulates in roots
CC and leaves of iron-deficient plants. {ECO:0000269|PubMed:11201743,
CC ECO:0000269|PubMed:15107503}.
CC -!- INDUCTION: Induced upon iron deficiency, but no effect of copper or
CC zinc starvation. {ECO:0000269|PubMed:11201743,
CC ECO:0000269|PubMed:15107503}.
CC -!- DISRUPTION PHENOTYPE: Plants display leaves with yellow stripes. Iron-
CC phytosiderophore transport is increased at low pH and inhibited by the
CC proton uncoupler CCCP. {ECO:0000269|PubMed:11201743}.
CC -!- SIMILARITY: Belongs to the YSL (TC 2.A.67.2) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF186234; AAG17016.2; -; mRNA.
DR RefSeq; NP_001104952.1; NM_001111482.1.
DR AlphaFoldDB; Q9AY27; -.
DR STRING; 4577.GRMZM2G156599_P01; -.
DR TCDB; 2.A.67.2.1; the oligopeptide transporter (opt) family.
DR PaxDb; Q9AY27; -.
DR PRIDE; Q9AY27; -.
DR GeneID; 541800; -.
DR MaizeGDB; 99123; -.
DR eggNOG; ENOG502QQ2H; Eukaryota.
DR OrthoDB; 525938at2759; -.
DR BioCyc; MetaCyc:MON-14020; -.
DR Proteomes; UP000007305; Unplaced.
DR ExpressionAtlas; Q9AY27; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051980; F:iron-nicotianamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0010039; P:response to iron ion; IBA:GO_Central.
DR GO; GO:0048316; P:seed development; IBA:GO_Central.
DR InterPro; IPR004813; OPT.
DR InterPro; IPR045035; YSL-like.
DR PANTHER; PTHR31645; PTHR31645; 1.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..682
FT /note="Iron-phytosiderophore transporter yellow stripe 1"
FT /id="PRO_0000311420"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 640..660
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 74418 MW; A55BC3CBF2015662 CRC64;
MDLARRGGAA GADDEGEIER HEPAPEDMES DPAAAREKEL ELERVQSWRE QVTLRGVVAA
LLIGFMYSVI VMKIALTTGL VPTLNVSAAL MAFLALRGWT RVLERLGVAH RPFTRQENCV
IETCAVACYT IAFGGGFGST LLGLDKKTYE LAGASPANVP GSYKDPGFGW MAGFVAAISF
AGLLSLIPLR KVLVIDYKLT YPSGTATAVL INGFHTKQGD KNARMQVRGF LKYFGLSFVW
SFFQWFYTGG EVCGFVQFPT FGLKAWKQTF FFDFSLTYVG AGMICSHLVN ISTLLGAILS
WGILWPLISK QKGEWYPANI PESSMKSLYG YKAFLCIALI MGDGTYHFFK VFGVTVKSLH
QRLSRKRATN RVANGGDEMA ALDDLQRDEI FSDGSFPAWA AYAGYAALTV VSAVIIPHMF
RQVKWYYVIV AYVLAPLLGF ANSYGTGLTD INMAYNYGKI ALFIFAAWAG RDNGVIAGLA
GGTLVKQLVM ASADLMHDFK TGHLTMTSPR SLLVAQFIGT AMGCVVAPLT FLLFYNAFDI
GNPTGYWKAP YGLIYRNMAI LGVEGFSVLP RHCLALSAGF FAFAFVFSVA RDVLPRKYAR
FVPLPMAMAV PFLVGGSFAI DMCVGSLAVF VWEKVNRKEA VFMVPAVASG LICGDGIWTF
PSSILALAKI KPPICMKFTP GS
