CBSX2_ARATH
ID CBSX2_ARATH Reviewed; 238 AA.
AC Q9C5D0; O49493;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=CBS domain-containing protein CBSX2, chloroplastic;
DE AltName: Full=CBS domain-containing protein 1;
DE Short=AtCDCP1;
DE AltName: Full=Protein LOSS OF THE TIMING OF ET AND JA BIOSYNTHESIS 1;
DE Short=AtLEJ1;
DE Flags: Precursor;
GN Name=CBSX2; Synonyms=CDCP1; OrderedLocusNames=At4g34120;
GN ORFNames=F28A23.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=18633119; DOI=10.1104/pp.108.124545;
RA Rutschow H., Ytterberg A.J., Friso G., Nilsson R., van Wijk K.J.;
RT "Quantitative proteomics of a chloroplast SRP54 sorting mutant and its
RT genetic interactions with CLPC1 in Arabidopsis.";
RL Plant Physiol. 148:156-175(2008).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19400948; DOI=10.1186/1471-2164-10-200;
RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
RT "Genome wide expression analysis of CBS domain containing proteins in
RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
RT developmental and stress regulation.";
RL BMC Genomics 10:200-200(2009).
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma
CC {ECO:0000269|PubMed:18633119}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021961; CAA17560.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161584; CAB80129.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86326.1; -; Genomic_DNA.
DR EMBL; AF360331; AAK26041.1; -; mRNA.
DR EMBL; AY056339; AAL07188.1; -; mRNA.
DR PIR; T05424; T05424.
DR RefSeq; NP_567952.1; NM_119573.5.
DR PDB; 3SL7; X-ray; 1.90 A; A/B=76-232.
DR PDB; 4GQY; X-ray; 2.19 A; A/B/C/D=76-238.
DR PDBsum; 3SL7; -.
DR PDBsum; 4GQY; -.
DR AlphaFoldDB; Q9C5D0; -.
DR SMR; Q9C5D0; -.
DR BioGRID; 14840; 1.
DR IntAct; Q9C5D0; 1.
DR STRING; 3702.AT4G34120.1; -.
DR PaxDb; Q9C5D0; -.
DR PRIDE; Q9C5D0; -.
DR ProteomicsDB; 223886; -.
DR EnsemblPlants; AT4G34120.1; AT4G34120.1; AT4G34120.
DR GeneID; 829558; -.
DR Gramene; AT4G34120.1; AT4G34120.1; AT4G34120.
DR KEGG; ath:AT4G34120; -.
DR Araport; AT4G34120; -.
DR TAIR; locus:2124276; AT4G34120.
DR eggNOG; ENOG502QTH1; Eukaryota.
DR HOGENOM; CLU_040681_4_0_1; -.
DR OMA; MLVQHRI; -.
DR OrthoDB; 1373724at2759; -.
DR PhylomeDB; Q9C5D0; -.
DR PRO; PR:Q9C5D0; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9C5D0; baseline and differential.
DR Genevisible; Q9C5D0; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0045454; P:cell redox homeostasis; IDA:TAIR.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR Pfam; PF00571; CBS; 2.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; SSF54631; 1.
DR PROSITE; PS51371; CBS; 2.
PE 1: Evidence at protein level;
KW 3D-structure; CBS domain; Chloroplast; Plastid; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..71
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 72..238
FT /note="CBS domain-containing protein CBSX2, chloroplastic"
FT /id="PRO_0000403933"
FT DOMAIN 83..145
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 177..234
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT HELIX 79..82
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 83..85
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 86..88
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 98..108
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 111..116
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 121..127
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 128..131
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 135..138
FT /evidence="ECO:0007829|PDB:4GQY"
FT HELIX 158..166
FT /evidence="ECO:0007829|PDB:3SL7"
FT TURN 167..170
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 173..176
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 177..180
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 190..197
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 204..208
FT /evidence="ECO:0007829|PDB:3SL7"
FT STRAND 213..219
FT /evidence="ECO:0007829|PDB:3SL7"
FT HELIX 220..232
FT /evidence="ECO:0007829|PDB:3SL7"
SQ SEQUENCE 238 AA; 25956 MW; BB51CC06F34C8060 CRC64;
MGSISLSNSM PITRLPLLTS LYHQSFLPIS SSSFSLLPLS NRRRSSTFSP SITVSAFFAA
PASVNNNNSV PAKNGGYTVG DFMTPRQNLH VVKPSTSVDD ALELLVEKKV TGLPVIDDNW
TLVGVVSDYD LLALDSISGR SQNDTNLFPD VDSTWKTFNE LQKLISKTYG KVVGDLMTPS
PLVVRDSTNL EDAARLLLET KFRRLPVVDA DGKLIGILTR GNVVRAALQI KRETENST
