ID   YSCR_YERPE              Reviewed;         217 AA.
AC   P69980; P40297; P42714; Q663J5;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Yop proteins translocation protein R;
GN   Name=yscR; OrderedLocusNames=YPCD1.44, y5034, y0037, YP_pCD39;
OS   Yersinia pestis.
OG   Plasmid pCD1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=8300512; DOI=10.1128/jb.176.3.569-579.1994;
RA   Fields K.A., Plano G.V., Straley S.C.;
RT   "A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB
RT   region of the LCR plasmid in Yersinia pestis.";
RL   J. Bacteriol. 176:569-579(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA   Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA   Blattner F.R.;
RT   "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT   Yersinia pestis KIM5.";
RL   Infect. Immun. 66:4611-4623(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Component of the yop secretion machinery. May have a role in
CC       the negative pathway regulation of yop expression controlled by
CC       calcium.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
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DR   EMBL; AF020214; AAB72201.1; -; Genomic_DNA.
DR   EMBL; AF074612; AAC69787.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62560.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54921.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58558.1; -; Genomic_DNA.
DR   PIR; B36955; B36955.
DR   RefSeq; NP_395178.1; NC_003131.1.
DR   RefSeq; NP_857738.1; NC_004836.1.
DR   RefSeq; NP_857933.1; NC_004839.1.
DR   RefSeq; WP_002212947.1; NZ_WUCM01000070.1.
DR   AlphaFoldDB; P69980; -.
DR   SMR; P69980; -.
DR   IntAct; P69980; 4.
DR   STRING; 214092.5832464; -.
DR   DNASU; 1149297; -.
DR   EnsemblBacteria; AAS58558; AAS58558; YP_pCD39.
DR   GeneID; 66841104; -.
DR   KEGG; ype:YPCD1.44; -.
DR   KEGG; ypm:YP_pCD39; -.
DR   PATRIC; fig|214092.21.peg.55; -.
DR   eggNOG; COG4790; Bacteria.
DR   HOGENOM; CLU_042028_2_0_6; -.
DR   OMA; IMITCFP; -.
DR   Proteomes; UP000000815; Plasmid pCD1.
DR   Proteomes; UP000001019; Plasmid pCD1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR005838; T3SS_IM_P.
DR   InterPro; IPR005773; YopR.
DR   PANTHER; PTHR30587; PTHR30587; 1.
DR   Pfam; PF00813; FliP; 1.
DR   PRINTS; PR01302; TYPE3IMPPROT.
DR   TIGRFAMs; TIGR01102; yscR; 1.
DR   PROSITE; PS01060; FLIP_1; 1.
DR   PROSITE; PS01061; FLIP_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..217
FT                   /note="Yop proteins translocation protein R"
FT                   /id="PRO_0000192000"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   217 AA;  24427 MW;  088CDA8F81959421 CRC64;
     MIQLPDEINL IIVLSLLTLL PLISVMATSF VKFAVVFSLL RNALGVQQIP PNMAMYGLAI
     ILSLYVMAPV GFATQDYLQA NEVSLTNIES VEKFFDEGLA PYRMFLKQHI QAQEYSFFVD
     STKQLWPKQY ADRLESDSLF ILLPAFTVSE LTRAFEIGFL IYLPFIVIDL VISNILLAMG
     MMMVSPMTIS LPFKLLLFVL LDGWTRLTHG LVISYGG