ID   YSCS_YERPE              Reviewed;          88 AA.
AC   P69982; P40298; P42715; Q663J4;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Yop proteins translocation protein S;
GN   Name=yscS; OrderedLocusNames=YPCD1.45, y5033, y0036, YP_pCD38;
OS   Yersinia pestis.
OG   Plasmid pCD1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=8300512; DOI=10.1128/jb.176.3.569-579.1994;
RA   Fields K.A., Plano G.V., Straley S.C.;
RT   "A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB
RT   region of the LCR plasmid in Yersinia pestis.";
RL   J. Bacteriol. 176:569-579(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RA   Payne P.L., Fields K.A., Straley S.C.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA   Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA   Blattner F.R.;
RT   "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT   Yersinia pestis KIM5.";
RL   Infect. Immun. 66:4611-4623(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Component of the Yop secretion machinery.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliQ/MopD/SpaQ family. {ECO:0000305}.
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DR   EMBL; AF020214; AAB72202.1; -; Genomic_DNA.
DR   EMBL; AF074612; AAC69786.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62559.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54922.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58557.1; -; Genomic_DNA.
DR   PIR; C36955; C36955.
DR   PIR; T43580; T43580.
DR   RefSeq; NP_395179.1; NC_003131.1.
DR   RefSeq; NP_857737.1; NC_004836.1.
DR   RefSeq; NP_857932.1; NC_004839.1.
DR   RefSeq; WP_002212945.1; NZ_WUCM01000070.1.
DR   AlphaFoldDB; P69982; -.
DR   SMR; P69982; -.
DR   IntAct; P69982; 2.
DR   MINT; P69982; -.
DR   STRING; 214092.5832465; -.
DR   EnsemblBacteria; AAS58557; AAS58557; YP_pCD38.
DR   GeneID; 66841103; -.
DR   KEGG; ype:YPCD1.45; -.
DR   KEGG; ypm:YP_pCD38; -.
DR   PATRIC; fig|214092.21.peg.56; -.
DR   eggNOG; COG4794; Bacteria.
DR   HOGENOM; CLU_164516_1_1_6; -.
DR   OMA; IQFINMA; -.
DR   Proteomes; UP000000815; Plasmid pCD1.
DR   Proteomes; UP000001019; Plasmid pCD1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR002191; Bac_export_3.
DR   InterPro; IPR006306; T3SS_HrpO.
DR   PANTHER; PTHR34040; PTHR34040; 1.
DR   Pfam; PF01313; Bac_export_3; 1.
DR   PIRSF; PIRSF004669; FliQ; 1.
DR   PRINTS; PR00952; TYPE3IMQPROT.
DR   TIGRFAMs; TIGR01403; fliQ_rel_III; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plasmid; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..88
FT                   /note="Yop proteins translocation protein S"
FT                   /id="PRO_0000129113"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        77..88
FT                   /note="AEMTMMKIQGIR -> VQK (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   88 AA;  9566 MW;  31F3B9EE616FA6E4 CRC64;
     MSQGDIIHFT SQALWLVLVL SMPPVLVAAV VGTLVSLVQA LTQIQEQTLG FVIKLIAVVV
     TLFATASWLG NELHSFAEMT MMKIQGIR