YSCU_YERPE
ID YSCU_YERPE Reviewed; 354 AA.
AC P69986; P40300; Q663J2;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Yop proteins translocation protein U;
GN Name=yscU; OrderedLocusNames=YPCD1.47, y5031, y0034, YP_pCD36;
OS Yersinia pestis.
OG Plasmid pCD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Component of the yop secretion machinery. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC {ECO:0000305}.
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DR EMBL; AF074612; AAC69784.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62556.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54924.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58555.1; -; Genomic_DNA.
DR PIR; T43578; T43578.
DR RefSeq; NP_395181.1; NC_003131.1.
DR RefSeq; NP_857735.1; NC_004836.1.
DR RefSeq; NP_857930.1; NC_004839.1.
DR RefSeq; WP_002212936.1; NZ_WUCM01000070.1.
DR PDB; 2JLH; X-ray; 1.53 A; A=211-354.
DR PDB; 2JLI; X-ray; 1.13 A; A=220-342.
DR PDB; 2JLJ; X-ray; 1.30 A; A=211-354.
DR PDBsum; 2JLH; -.
DR PDBsum; 2JLI; -.
DR PDBsum; 2JLJ; -.
DR AlphaFoldDB; P69986; -.
DR BMRB; P69986; -.
DR SMR; P69986; -.
DR IntAct; P69986; 3.
DR MINT; P69986; -.
DR STRING; 214092.5832467; -.
DR MEROPS; N06.001; -.
DR DNASU; 1149294; -.
DR EnsemblBacteria; AAS58555; AAS58555; YP_pCD36.
DR GeneID; 66841101; -.
DR KEGG; ype:YPCD1.47; -.
DR KEGG; ypm:YP_pCD36; -.
DR PATRIC; fig|214092.21.peg.58; -.
DR eggNOG; COG4792; Bacteria.
DR HOGENOM; CLU_041013_1_3_6; -.
DR OMA; DPHHKAK; -.
DR EvolutionaryTrace; P69986; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.1690.10; -; 1.
DR InterPro; IPR006307; BsaZ.
DR InterPro; IPR006135; T3SS_substrate_exporter.
DR InterPro; IPR029025; T3SS_substrate_exporter_C.
DR PANTHER; PTHR30531; PTHR30531; 1.
DR Pfam; PF01312; Bac_export_2; 1.
DR PRINTS; PR00950; TYPE3IMSPROT.
DR SUPFAM; SSF160544; SSF160544; 1.
DR TIGRFAMs; TIGR01404; FlhB_rel_III; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Plasmid; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Virulence.
FT CHAIN 1..354
FT /note="Yop proteins translocation protein U"
FT /id="PRO_0000180961"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 241..255
FT /evidence="ECO:0007829|PDB:2JLI"
FT STRAND 258..263
FT /evidence="ECO:0007829|PDB:2JLI"
FT STRAND 266..272
FT /evidence="ECO:0007829|PDB:2JLI"
FT TURN 275..277
FT /evidence="ECO:0007829|PDB:2JLI"
FT STRAND 282..288
FT /evidence="ECO:0007829|PDB:2JLI"
FT HELIX 291..302
FT /evidence="ECO:0007829|PDB:2JLI"
FT STRAND 306..308
FT /evidence="ECO:0007829|PDB:2JLI"
FT HELIX 310..319
FT /evidence="ECO:0007829|PDB:2JLI"
FT HELIX 328..330
FT /evidence="ECO:0007829|PDB:2JLI"
FT HELIX 331..338
FT /evidence="ECO:0007829|PDB:2JLI"
SQ SEQUENCE 354 AA; 40382 MW; BFD4977E22D2D3A3 CRC64;
MSGEKTEQPT PKKIRDARKK GQVAKSKEVV STALIVALSA MLMGLSDYYF EHFSKLMLIP
AEQSYLPFSQ ALSYVVDNVL LEFFYLCFPL LTVAALMAIA SHVVQYGFLI SGEAIKPDIK
KINPIEGAKR IFSIKSLVEF LKSILKVVLL SILIWIIIKG NLVTLLQLPT CGIECITPLL
GQILRQLMVI CTVGFVVISI ADYAFEYYQY IKELKMSKDE IKREYKEMEG SPEIKSKRRQ
FHQEIQSRNM RENVKRSSVV VANPTHIAIG ILYKRGETPL PLVTFKYTDA QVQTVRKIAE
EEGVPILQRI PLARALYWDA LVDHYIPAEQ IEATAEVLRW LERQNIEKQH SEML
