ID   YSCU_YERPS              Reviewed;         354 AA.
AC   P69987; P40300; Q663J2;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Yop proteins translocation protein U;
GN   Name=yscU; OrderedLocusNames=pYV0074;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OG   Plasmid pIB1, and Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YPIII / Serotype O:3; PLASMID=pIB1;
RX   PubMed=8169210; DOI=10.1128/jb.176.9.2619-2626.1994;
RA   Bergman T., Erickson K., Galyov E., Persson C., Wolf-Watz H.;
RT   "The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved
RT   in Yop secretion and shows high homology to the spa gene clusters of
RT   Shigella flexneri and Salmonella typhimurium.";
RL   J. Bacteriol. 176:2619-2626(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953; PLASMID=pYV;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Component of the yop secretion machinery.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000305}.
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DR   EMBL; L25667; AAA27681.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25417.1; -; Genomic_DNA.
DR   RefSeq; WP_002212936.1; NZ_CP009711.1.
DR   PDB; 2ML9; NMR; -; A=211-263.
DR   PDBsum; 2ML9; -.
DR   AlphaFoldDB; P69987; -.
DR   BMRB; P69987; -.
DR   SMR; P69987; -.
DR   MEROPS; N06.001; -.
DR   EnsemblBacteria; CAF25417; CAF25417; pYV0074.
DR   GeneID; 66841101; -.
DR   KEGG; ypo:BZ17_4260; -.
DR   KEGG; yps:pYV0074; -.
DR   PATRIC; fig|273123.14.peg.4496; -.
DR   OMA; DPHHKAK; -.
DR   PHI-base; PHI:7903; -.
DR   Proteomes; UP000001011; Plasmid pYV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; -; 1.
DR   InterPro; IPR006307; BsaZ.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   PANTHER; PTHR30531; PTHR30531; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; SSF160544; 1.
DR   TIGRFAMs; TIGR01404; FlhB_rel_III; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Membrane; Plasmid; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..354
FT                   /note="Yop proteins translocation protein U"
FT                   /id="PRO_0000180962"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           211..229
FT                   /evidence="ECO:0007829|PDB:2ML9"
FT   HELIX           233..246
FT                   /evidence="ECO:0007829|PDB:2ML9"
FT   HELIX           250..253
FT                   /evidence="ECO:0007829|PDB:2ML9"
SQ   SEQUENCE   354 AA;  40382 MW;  BFD4977E22D2D3A3 CRC64;
     MSGEKTEQPT PKKIRDARKK GQVAKSKEVV STALIVALSA MLMGLSDYYF EHFSKLMLIP
     AEQSYLPFSQ ALSYVVDNVL LEFFYLCFPL LTVAALMAIA SHVVQYGFLI SGEAIKPDIK
     KINPIEGAKR IFSIKSLVEF LKSILKVVLL SILIWIIIKG NLVTLLQLPT CGIECITPLL
     GQILRQLMVI CTVGFVVISI ADYAFEYYQY IKELKMSKDE IKREYKEMEG SPEIKSKRRQ
     FHQEIQSRNM RENVKRSSVV VANPTHIAIG ILYKRGETPL PLVTFKYTDA QVQTVRKIAE
     EEGVPILQRI PLARALYWDA LVDHYIPAEQ IEATAEVLRW LERQNIEKQH SEML