ID   YSDB_BACSU              Reviewed;         130 AA.
AC   P94520; Q795W5;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Sigma-w pathway protein YsdB;
GN   Name=ysdB; OrderedLocusNames=BSU28830;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969504; DOI=10.1099/13500872-142-11-3067;
RA   Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J.,
RA   Emmerson P.T., Harwood C.R.;
RT   "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis
RT   chromosome containing genes responsible for stress responses, the
RT   utilization of plant cell walls and primary metabolism.";
RL   Microbiology 142:3067-3078(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION.
RX   PubMed=12207695; DOI=10.1046/j.1365-2958.2002.03050.x;
RA   Cao M., Wang T., Ye R., Helmann J.D.;
RT   "Antibiotics that inhibit cell wall biosynthesis induce expression of the
RT   Bacillus subtilis sigma(W) and sigma(M) regulons.";
RL   Mol. Microbiol. 45:1267-1276(2002).
RN   [4]
RP   FUNCTION.
RX   PubMed=16816000; DOI=10.1101/gad.1440606;
RA   Ellermeier C.D., Losick R.;
RT   "Evidence for a novel protease governing regulated intramembrane
RT   proteolysis and resistance to antimicrobial peptides in Bacillus
RT   subtilis.";
RL   Genes Dev. 20:1911-1922(2006).
CC   -!- FUNCTION: May mediate a negative feedback loop that down-regulates the
CC       expression of the sigma-W regulon following the activation of sigma-W
CC       in response to conditions of cell envelope stress. Might interact with
CC       and inhibit the activity of the protease PrsW, or could bind to the
CC       anti-sigma-W factor RsiW and thereby protect it from PrsW-mediated
CC       cleavage. {ECO:0000269|PubMed:16816000}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Expressed under the control of the sigma-W factor.
CC       {ECO:0000269|PubMed:12207695}.
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DR   EMBL; Z75208; CAA99584.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14843.1; -; Genomic_DNA.
DR   PIR; H69983; H69983.
DR   RefSeq; NP_390761.1; NC_000964.3.
DR   RefSeq; WP_003229493.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P94520; -.
DR   SMR; P94520; -.
DR   STRING; 224308.BSU28830; -.
DR   PaxDb; P94520; -.
DR   PRIDE; P94520; -.
DR   DNASU; 937429; -.
DR   EnsemblBacteria; CAB14843; CAB14843; BSU_28830.
DR   GeneID; 937429; -.
DR   KEGG; bsu:BSU28830; -.
DR   PATRIC; fig|224308.179.peg.3131; -.
DR   eggNOG; ENOG5030CKE; Bacteria.
DR   OMA; VMFEGEK; -.
DR   BioCyc; BSUB:BSU28830-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..130
FT                   /note="Sigma-w pathway protein YsdB"
FT                   /id="PRO_0000248144"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  15572 MW;  ECEBFB884DFEE64D CRC64;
     MFVMVLRIIL LALFAYCIYA VVKYVANPKR RLKLAQSKEH FYIIDEQNNT RKNFQLTYKG
     VLFEGEKHIP SKDHPLFIHT IFVWTESPEK LKHFSAKDFE NIEEKVLERY PNCKIDWDQP
     IKLAKKAEER