YSF3_YEAST
ID YSF3_YEAST Reviewed; 85 AA.
AC P0C074; D6W143;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=RDS3 complex subunit 10;
DE AltName: Full=Splicing factor 3b subunit;
GN Name=YSF3; Synonyms=RCP10; OrderedLocusNames=YNL138W-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [4]
RP IDENTIFICATION IN THE SF3B COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=15565172; DOI=10.1038/sj.emboj.7600482;
RA Dziembowski A., Ventura A.-P., Rutz B., Caspary F., Faux C., Halgand F.,
RA Laprevote O., Seraphin B.;
RT "Proteomic analysis identifies a new complex required for nuclear pre-mRNA
RT retention and splicing.";
RL EMBO J. 23:4847-4856(2004).
RN [5]
RP IDENTIFICATION IN THE SF3B COMPLEX, FUNCTION, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16314500; DOI=10.1128/mcb.25.24.10745-10754.2005;
RA Wang Q., He J., Lynn B., Rymond B.C.;
RT "Interactions of the yeast SF3b splicing factor.";
RL Mol. Cell. Biol. 25:10745-10754(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing. Required for the SF3b
CC integrity and prespliceosome assembly. {ECO:0000269|PubMed:16314500}.
CC -!- SUBUNIT: Belongs to the SF3b complex composed of CUS1, HSH49, HSH155,
CC RCP1, RDS3 and RSE1. {ECO:0000269|PubMed:15565172,
CC ECO:0000269|PubMed:16314500}.
CC -!- INTERACTION:
CC P0C074; P49955: HSH155; NbExp=3; IntAct=EBI-970846, EBI-664;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; Z71414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z71416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006947; DAA10409.1; -; Genomic_DNA.
DR RefSeq; NP_878153.1; NM_001184519.1.
DR PDB; 5GM6; EM; 3.50 A; K=1-85.
DR PDB; 5LQW; EM; 5.80 A; Z=1-85.
DR PDB; 5NRL; EM; 7.20 A; Z=1-85.
DR PDB; 5ZWM; EM; 3.40 A; 6=1-85.
DR PDB; 5ZWO; EM; 3.90 A; 6=1-85.
DR PDB; 6G90; EM; 4.00 A; Z=1-85.
DR PDB; 7DCO; EM; 2.50 A; 6=1-84.
DR PDB; 7OQB; EM; 9.00 A; Z=1-84.
DR PDB; 7OQE; EM; 5.90 A; Z=1-85.
DR PDBsum; 5GM6; -.
DR PDBsum; 5LQW; -.
DR PDBsum; 5NRL; -.
DR PDBsum; 5ZWM; -.
DR PDBsum; 5ZWO; -.
DR PDBsum; 6G90; -.
DR PDBsum; 7DCO; -.
DR PDBsum; 7OQB; -.
DR PDBsum; 7OQE; -.
DR AlphaFoldDB; P0C074; -.
DR SMR; P0C074; -.
DR BioGRID; 37053; 43.
DR ComplexPortal; CPX-1647; SF3B complex.
DR ComplexPortal; CPX-26; U2 small nuclear ribonucleoprotein complex.
DR IntAct; P0C074; 9.
DR MINT; P0C074; -.
DR STRING; 4932.YNL138W-A; -.
DR PaxDb; P0C074; -.
DR PRIDE; P0C074; -.
DR TopDownProteomics; P0C074; -.
DR EnsemblFungi; YNL138W-A_mRNA; YNL138W-A; YNL138W-A.
DR GeneID; 1466511; -.
DR KEGG; sce:YNL138W-A; -.
DR SGD; S000028509; YSF3.
DR VEuPathDB; FungiDB:YNL138W-A; -.
DR eggNOG; KOG3485; Eukaryota.
DR HOGENOM; CLU_138804_4_1_1; -.
DR InParanoid; P0C074; -.
DR OMA; MKQKHIG; -.
DR BioCyc; YEAST:G3O-33408-MON; -.
DR PRO; PR:P0C074; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P0C074; protein.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IC:ComplexPortal.
DR GO; GO:0005686; C:U2 snRNP; IDA:SGD.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IPI:ComplexPortal.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IMP:SGD.
DR GO; GO:1903241; P:U2-type prespliceosome assembly; IC:ComplexPortal.
DR InterPro; IPR009846; SF3b5/RDS3-10.
DR Pfam; PF07189; SF3b10; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT CHAIN 1..85
FT /note="RDS3 complex subunit 10"
FT /id="PRO_0000097203"
SQ SEQUENCE 85 AA; 10027 MW; 32AC005006433E6D CRC64;
MAEKQRQLKL QKIYKQKYIG LGDESTTREQ WQRNVRNDTL NTLQGHSASL EYVSLSRGDL
SIRDTRIHLL KSMSPGYKAY LREER
