CBT1_YEAST
ID CBT1_YEAST Reviewed; 271 AA.
AC P36038; D6VWZ5; Q6Q574;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cytochrome b termination protein 1;
GN Name=CBT1; Synonyms=SOC1; OrderedLocusNames=YKL208W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=7851755; DOI=10.1093/genetics/138.3.565;
RA Staples R.R., Dieckmann C.L.;
RT "Suppressor analyses of temperature-sensitive cbp1 strains of Saccharomyces
RT cerevisiae: the product of the nuclear gene SOC1 affects mitochondrial
RT cytochrome b mRNA post-transcriptionally.";
RL Genetics 138:565-575(1994).
RN [5]
RP FUNCTION.
RX PubMed=9339340; DOI=10.1007/s002940050262;
RA Rieger K.-J., Aljinovic G., Lazowska J., Pohl T.M., Slonimski P.P.,
RA Aljinovic G.;
RT "A novel nuclear gene, CBT1, essential for mitochondrial cytochrome b
RT formation: terminal processing of mRNA and intron dependence.";
RL Curr. Genet. 32:163-174(1997).
RN [6]
RP FUNCTION.
RX PubMed=10101159; DOI=10.1093/genetics/151.4.1315;
RA Chen W., Islas-Osuna M.A., Dieckmann C.L.;
RT "Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA
RT identifies components of general pathways for mitochondrial mRNA processing
RT and decay in Saccharomyces cerevisiae.";
RL Genetics 151:1315-1325(1999).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [8]
RP FUNCTION.
RX PubMed=16118200; DOI=10.1534/genetics.104.036467;
RA Ellis T.P., Schonauer M.S., Dieckmann C.L.;
RT "CBT1 interacts genetically with CBP1 and the mitochondrially encoded
RT cytochrome b gene and is required to stabilize the mature cytochrome b mRNA
RT of Saccharomyces cerevisiae.";
RL Genetics 171:949-957(2005).
CC -!- FUNCTION: Involved in 5'-end processing of mitochondrial COB, 15S rRNA,
CC and RPM1 transcript. May also have a role in 3'-end processing of the
CC COB pre-mRNA. {ECO:0000269|PubMed:10101159,
CC ECO:0000269|PubMed:16118200, ECO:0000269|PubMed:7851755,
CC ECO:0000269|PubMed:9339340}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
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DR EMBL; Z28208; CAA82053.1; -; Genomic_DNA.
DR EMBL; AY558395; AAS56721.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA08961.1; -; Genomic_DNA.
DR PIR; S38046; S38046.
DR RefSeq; NP_012714.1; NM_001179773.1.
DR AlphaFoldDB; P36038; -.
DR SMR; P36038; -.
DR BioGRID; 33958; 292.
DR DIP; DIP-3855N; -.
DR STRING; 4932.YKL208W; -.
DR iPTMnet; P36038; -.
DR PaxDb; P36038; -.
DR PRIDE; P36038; -.
DR EnsemblFungi; YKL208W_mRNA; YKL208W; YKL208W.
DR GeneID; 853673; -.
DR KEGG; sce:YKL208W; -.
DR SGD; S000001691; CBT1.
DR VEuPathDB; FungiDB:YKL208W; -.
DR eggNOG; ENOG502S6VE; Eukaryota.
DR HOGENOM; CLU_090080_0_0_1; -.
DR InParanoid; P36038; -.
DR OMA; DYYWNLF; -.
DR BioCyc; YEAST:G3O-31967-MON; -.
DR PRO; PR:P36038; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36038; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0017004; P:cytochrome complex assembly; IDA:SGD.
DR GO; GO:0006397; P:mRNA processing; IDA:SGD.
DR GO; GO:0048255; P:mRNA stabilization; IMP:SGD.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Mitochondrion; mRNA processing; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..271
FT /note="Cytochrome b termination protein 1"
FT /id="PRO_0000203131"
FT CONFLICT 270
FT /note="R -> Q (in Ref. 3; AAS56721)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31157 MW; 6022348CA619123C CRC64;
MVSYGSHSSE VSKVLKTPKF VLRYGNVSSK QRFALKRKIN YKLRESKYQE YLNEYNTFVL
YDWENSGAGS LVDSSYNLPS LWKEFITEGI SKGAINDKLP TVFMKRKLTN SALGHCLGLD
FLTDPSESEH EYRCMFQTVQ DIPSLSQLIL FNSMPNVPVR LKLHTIGINI NFGCKRSLIS
NGGDQDTEMS EAVSYIQPLL EESSRMYRNL NYWKLLKIAR NNKKDEPLDQ STRIKSQVKL
LLSQLATNRI TSPSVTDHGG HNWLIFTRRR L
