YSL3_ARATH
ID YSL3_ARATH Reviewed; 675 AA.
AC Q2EF88; Q0WVQ4; Q9FJC8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Metal-nicotianamine transporter YSL3;
DE AltName: Full=Protein YELLOW STRIPE LIKE 3;
DE Short=AtYSL3;
GN Name=YSL3; OrderedLocusNames=At5g53550; ORFNames=MNC6.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16815956; DOI=10.1104/pp.106.082586;
RA Waters B.M., Chu H.-H., DiDonato R.J. Jr., Roberts L.A., Eisley R.B.,
RA Lahner B., Salt D.E., Walker E.L.;
RT "Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3
RT reveal their roles in metal ion homeostasis and loading of metal ions in
RT seeds.";
RL Plant Physiol. 141:1446-1458(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-675.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the lateral transport of nicotianamine-
CC chelated metals in the vasculature. {ECO:0000269|PubMed:16815956}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, anthers and pollen grains.
CC Restricted to the vasculature. {ECO:0000269|PubMed:16815956}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during leaf senescence.
CC {ECO:0000269|PubMed:16815956}.
CC -!- INDUCTION: Slight induction by manganese, copper or zinc deficiency.
CC Inhibited upon iron deficiency and induced by iron overload.
CC {ECO:0000269|PubMed:16815956}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:16815956}.
CC -!- SIMILARITY: Belongs to the YSL (TC 2.A.67.2) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09731.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ385057; ABD38920.1; -; mRNA.
DR EMBL; AB015476; BAB09731.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96375.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96376.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70470.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70472.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70473.1; -; Genomic_DNA.
DR EMBL; AK226687; BAE98794.1; -; mRNA.
DR RefSeq; NP_001190532.1; NM_001203603.2.
DR RefSeq; NP_001332078.1; NM_001345064.1.
DR RefSeq; NP_001332080.1; NM_001345063.1.
DR RefSeq; NP_001332081.1; NM_001345061.1.
DR RefSeq; NP_200167.2; NM_124735.4.
DR AlphaFoldDB; Q2EF88; -.
DR BioGRID; 20681; 9.
DR IntAct; Q2EF88; 9.
DR STRING; 3702.AT5G53550.2; -.
DR TCDB; 2.A.67.2.4; the oligopeptide transporter (opt) family.
DR PaxDb; Q2EF88; -.
DR PRIDE; Q2EF88; -.
DR ProteomicsDB; 242353; -.
DR EnsemblPlants; AT5G53550.1; AT5G53550.1; AT5G53550.
DR EnsemblPlants; AT5G53550.2; AT5G53550.2; AT5G53550.
DR EnsemblPlants; AT5G53550.3; AT5G53550.3; AT5G53550.
DR EnsemblPlants; AT5G53550.5; AT5G53550.5; AT5G53550.
DR EnsemblPlants; AT5G53550.6; AT5G53550.6; AT5G53550.
DR GeneID; 835437; -.
DR Gramene; AT5G53550.1; AT5G53550.1; AT5G53550.
DR Gramene; AT5G53550.2; AT5G53550.2; AT5G53550.
DR Gramene; AT5G53550.3; AT5G53550.3; AT5G53550.
DR Gramene; AT5G53550.5; AT5G53550.5; AT5G53550.
DR Gramene; AT5G53550.6; AT5G53550.6; AT5G53550.
DR KEGG; ath:AT5G53550; -.
DR Araport; AT5G53550; -.
DR TAIR; locus:2168656; AT5G53550.
DR eggNOG; ENOG502QQ2H; Eukaryota.
DR HOGENOM; CLU_015477_2_0_1; -.
DR InParanoid; Q2EF88; -.
DR OMA; HIVVSQY; -.
DR OrthoDB; 525938at2759; -.
DR PhylomeDB; Q2EF88; -.
DR PRO; PR:Q2EF88; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q2EF88; baseline and differential.
DR Genevisible; Q2EF88; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0051980; F:iron-nicotianamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0003006; P:developmental process involved in reproduction; IGI:TAIR.
DR GO; GO:0010039; P:response to iron ion; IBA:GO_Central.
DR GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR GO; GO:0048316; P:seed development; IGI:TAIR.
DR InterPro; IPR004813; OPT.
DR InterPro; IPR045035; YSL-like.
DR PANTHER; PTHR31645; PTHR31645; 1.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..675
FT /note="Metal-nicotianamine transporter YSL3"
FT /id="PRO_0000311414"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 675 AA; 74149 MW; 9F0A92BB75A20C27 CRC64;
MRSMMMEREG RNEIEREVID DLEETQNEGD DFKSIPPWKE QITFRGIVAS LIIGIIYSVI
VMKLNLTTGL VPNLNVSAAL LAFVFLRSWT KLLTKAGIVT KPFTKQENTV VQTCAVACYS
IAVGGGFGSY LLGLNRITYE QSGGTHTDGN YPEGTKEPGI GWMTAFLFFT CFVGLLALVP
LRKIMIIDYK LTYPSGTATA VLINGFHTPK GNKMAKKQVF GFVKYFSFSF IWAFFQWFFS
GGTECGFIQF PTFGLEALKN TFYFDFSMTY VGAGMICPHI VNISLLFGAV LSWGIMWPLI
KGLKGDWFPS TLPENSMKSL NGYKVFISIS LILGDGLYQF IKILFKTGIN MYVKLNNRNS
GKSNSEKDKQ SIADLKRDEI FVRDSIPLWV AAVGYAAFSV VSIIAIPIMF PELKWYFIVV
AYMLAPSLGF SNAYGAGLTD MNMAYNYGKV ALFILAAMAG KQNGVVAGLV GCGLIKSIVS
ISSDLMHDFK TGHLTLTSPR SMLVSQAIGT AIGCVVAPLT FFLFYKAFDV GNQEGEYKAP
YALVYRNMAI LGVEGFSALP QHCLQLCYGF FAFAVAANLV RDRLPDKIGN WVPLPMAMAV
PFLVGGYFAI DMCVGSLIVF AWNMRDRVKA GLMVPAVASG LICGDGLWIL PSSVLALAGV
RPPICMGFMP SKYSS
