ID   CBTA_ECOL6              Reviewed;         124 AA.
AC   P64525; P76365;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Toxin CbtA;
DE   AltName: Full=Toxin YeeV;
GN   Name=cbtA; Synonyms=yeeV; OrderedLocusNames=c2532;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Toxic component of a type IV toxin-antitoxin (TA) system.
CC       Acts as a dual toxin inhibitor that blocks cell division and cell
CC       elongation in genetically separable interactions with FtsZ and MreB.
CC       Toxic effects are neutralized by cognate antitoxin CbeA (A0A0H2V8S8),
CC       although there is no direct interaction detected between the 2
CC       proteins. {ECO:0000250|UniProtKB:P64524}.
CC   -!- SUBUNIT: Interacts with FtsZ. Interacts with MreB.
CC       {ECO:0000250|UniProtKB:P64524}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P64524}.
CC   -!- SIMILARITY: Belongs to the CbtA/YkfI/YpjF toxin family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN80986.1; -; Genomic_DNA.
DR   RefSeq; WP_000854814.1; NC_004431.1.
DR   AlphaFoldDB; P64525; -.
DR   STRING; 199310.c2532; -.
DR   EnsemblBacteria; AAN80986; AAN80986; c2532.
DR   GeneID; 58391593; -.
DR   KEGG; ecc:c2532; -.
DR   eggNOG; ENOG5030KUQ; Bacteria.
DR   HOGENOM; CLU_129204_1_0_6; -.
DR   BioCyc; ECOL199310:C2532-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009610; CbtA_toxin.
DR   Pfam; PF06755; CbtA_toxin; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Toxin-antitoxin system.
FT   CHAIN           1..124
FT                   /note="Toxin CbtA"
FT                   /id="PRO_0000169117"
SQ   SEQUENCE   124 AA;  13899 MW;  4327D21EC2A8159A CRC64;
     MKTLPVLPGQ AASSRPSPVE IWQILLSRLL DQHYGLTLND TPFADERVIE QHIEAGISLC
     DAVNFLVEKY ALVRTDQPGF SACTRSQLIN SIDILRARRA TGLMTRDNYR TVNNITLGKY
     PEAK