CBWD1_RAT
ID CBWD1_RAT Reviewed; 394 AA.
AC Q99MB4; Q5RK12;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=COBW domain-containing protein 1;
DE AltName: Full=Cobalamin synthase W domain-containing protein 1;
GN Name=Cbwd1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Shi J., Cai W., Xie Y.Y., Ying K., Wu C., Zhou Z.;
RT "Molecular cloning and characterization of a new dopamine-inducible LIM-
RT domain transcription factor from cultured astrocytes.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. CobW
CC subfamily. {ECO:0000305}.
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DR EMBL; AF353305; AAK31208.1; -; mRNA.
DR EMBL; BC086376; AAH86376.1; -; mRNA.
DR RefSeq; NP_598219.2; NM_133535.2.
DR AlphaFoldDB; Q99MB4; -.
DR SMR; Q99MB4; -.
DR STRING; 10116.ENSRNOP00000021185; -.
DR jPOST; Q99MB4; -.
DR PaxDb; Q99MB4; -.
DR PRIDE; Q99MB4; -.
DR Ensembl; ENSRNOT00000021185; ENSRNOP00000021185; ENSRNOG00000015516.
DR GeneID; 171057; -.
DR KEGG; rno:171057; -.
DR CTD; 55871; -.
DR RGD; 708495; Cbwd1.
DR eggNOG; KOG2743; Eukaryota.
DR GeneTree; ENSGT00640000091523; -.
DR HOGENOM; CLU_017452_0_1_1; -.
DR InParanoid; Q99MB4; -.
DR OMA; MWGVLRY; -.
DR OrthoDB; 1144889at2759; -.
DR PhylomeDB; Q99MB4; -.
DR TreeFam; TF332679; -.
DR PRO; PR:Q99MB4; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000015516; Expressed in testis and 19 other tissues.
DR Genevisible; Q99MB4; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1220.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR011629; Cbl_biosynth_CobW-like_C.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..394
FT /note="COBW domain-containing protein 1"
FT /id="PRO_0000245525"
FT DOMAIN 272..375
FT /note="CobW C-terminal"
FT BINDING 48..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 109..113
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 202..205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 81
FT /note="S -> N (in Ref. 1; AAK31208)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="W -> R (in Ref. 1; AAK31208)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 394 AA; 43931 MW; 3D14334F74ED474D CRC64;
MLPAMKTVEA EEEYAEDCPE LVPIETKHQE KEENLDFIIK IPVTIVTGYL GAGKTTLLNY
ILTEQHNRKI AVILNEFGEG SAVEKSLAVS QGGELYEEWL ELRNGCLCCS VKDNGLKAIE
NLMQKKGKFD YILLETTGLA DPGAVASMFW VDAELGSDIY LDGIITVVDS KYGLKHLTEE
KPDGLVNEAT RQVALADMIL INKTDLVSEE ELNKLRTTIR SINGLGKVLE TQRSRTHLSN
ILDLHAYDTL SGISLQKKLQ HVSTAPHLDQ SIVTVTFDVP GSAEEESLNV FIQNLLWEKN
VKNKDGRCME VIRLKGLVSI KDKPQQMIVQ GIHELYELEE SRVNWKDDAE RACQLVFIGK
NLDKDILQQL FITAVAETKE QTTAPGQDGA CPPH
