YSXA_BACSU
ID YSXA_BACSU Reviewed; 231 AA.
AC Q02170;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=UPF0758 protein YsxA;
GN Name=ysxA; OrderedLocusNames=BSU28040;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1400224; DOI=10.1128/jb.174.21.6717-6728.1992;
RA Levin P.A., Margolis P.S., Setlow P., Losick R., Sun D.;
RT "Identification of Bacillus subtilis genes for septum placement and shape
RT determination.";
RL J. Bacteriol. 174:6717-6728(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8387996; DOI=10.1128/jb.175.10.3139-3145.1993;
RA Butler Y.X., Abhayawardhane Y., Stewart G.C.;
RT "Amplification of the Bacillus subtilis maf gene results in arrested septum
RT formation.";
RL J. Bacteriol. 175:3139-3145(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-231.
RX PubMed=1400225; DOI=10.1128/jb.174.21.6729-6742.1992;
RA Varley A.W., Stewart G.C.;
RT "The divIVB region of the Bacillus subtilis chromosome encodes homologs of
RT Escherichia coli septum placement (minCD) and cell shape (mreBCD)
RT determinants.";
RL J. Bacteriol. 174:6729-6742(1992).
RN [5]
RP INDUCTION.
RC STRAIN=168 / 1604;
RX PubMed=17434969; DOI=10.1128/jb.00130-07;
RA Jervis A.J., Thackray P.D., Houston C.W., Horsburgh M.J., Moir A.;
RT "SigM-responsive genes of Bacillus subtilis and their promoters.";
RL J. Bacteriol. 189:4534-4538(2007).
CC -!- INDUCTION: Transcribed under partial control of SigM ECF sigma factor
CC (PubMed:17434969). {ECO:0000269|PubMed:17434969}.
CC -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M96343; AAA22396.1; -; Genomic_DNA.
DR EMBL; L08793; AAA22583.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14764.1; -; Genomic_DNA.
DR PIR; B45239; B45239.
DR RefSeq; NP_390682.1; NC_000964.3.
DR RefSeq; WP_003246034.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; Q02170; -.
DR SMR; Q02170; -.
DR STRING; 224308.BSU28040; -.
DR PaxDb; Q02170; -.
DR PRIDE; Q02170; -.
DR EnsemblBacteria; CAB14764; CAB14764; BSU_28040.
DR GeneID; 936544; -.
DR KEGG; bsu:BSU28040; -.
DR PATRIC; fig|224308.179.peg.3046; -.
DR eggNOG; COG2003; Bacteria.
DR InParanoid; Q02170; -.
DR OMA; AMPDYEL; -.
DR PhylomeDB; Q02170; -.
DR BioCyc; BSUB:BSU28040-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR CDD; cd08071; MPN_DUF2466; 1.
DR InterPro; IPR000445; HhH_motif.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR025657; RadC_JAB.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001405; UPF0758.
DR InterPro; IPR020891; UPF0758_CS.
DR PANTHER; PTHR30471; PTHR30471; 1.
DR Pfam; PF00633; HHH; 1.
DR Pfam; PF04002; RadC; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR TIGRFAMs; TIGR00608; radc; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS01302; UPF0758; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW Zinc.
FT CHAIN 1..231
FT /note="UPF0758 protein YsxA"
FT /id="PRO_0000190683"
FT DOMAIN 109..231
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT MOTIF 180..193
FT /note="JAMM motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 180
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 182
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 193
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 231 AA; 26146 MW; B93FC0528C5B49F4 CRC64;
MVIHDLPLKL KDFPMKEKPR ERLLKVGAEN LANHELLAIL LRTGTKHESV LDLSNRLLRS
FDGLRLLKEA SVEELSSIPG IGMVKAIQIL AAVELGSRIH KLANEEHFVI RSPEDGANLV
MEDMRFLTQE HFVCLYLNTK NQVIHKRTVF IGSLNSSIVH PREVFKEAFK RSAASFICVH
NHPSGDPTPS REDIEVTRRL FECGNLIGIE LLDHLVIGDK KFVSLKEKGY L
