YT13_CAEEL
ID YT13_CAEEL Reviewed; 484 AA.
AC Q10917; Q7YZF8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Putative transporter B0252.3;
GN ORFNames=B0252.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q10917-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q10917-2; Sequence=VSP_009463;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; FO080139; CCD61538.1; -; Genomic_DNA.
DR EMBL; FO080139; CCD61539.1; -; Genomic_DNA.
DR PIR; T15290; T15290.
DR RefSeq; NP_001021887.1; NM_001026716.4.
DR RefSeq; NP_001021888.1; NM_001026717.4. [Q10917-1]
DR AlphaFoldDB; Q10917; -.
DR SMR; Q10917; -.
DR BioGRID; 39468; 1.
DR IntAct; Q10917; 1.
DR STRING; 6239.B0252.3b; -.
DR EPD; Q10917; -.
DR PaxDb; Q10917; -.
DR PeptideAtlas; Q10917; -.
DR EnsemblMetazoa; B0252.3a.1; B0252.3a.1; WBGene00015088. [Q10917-2]
DR EnsemblMetazoa; B0252.3a.2; B0252.3a.2; WBGene00015088. [Q10917-2]
DR EnsemblMetazoa; B0252.3a.3; B0252.3a.3; WBGene00015088. [Q10917-2]
DR EnsemblMetazoa; B0252.3a.4; B0252.3a.4; WBGene00015088. [Q10917-2]
DR EnsemblMetazoa; B0252.3b.1; B0252.3b.1; WBGene00015088. [Q10917-1]
DR GeneID; 174130; -.
DR KEGG; cel:CELE_B0252.3; -.
DR UCSC; B0252.3b; c. elegans. [Q10917-1]
DR CTD; 174130; -.
DR WormBase; B0252.3a; CE32095; WBGene00015088; -. [Q10917-2]
DR WormBase; B0252.3b; CE34631; WBGene00015088; -. [Q10917-1]
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000164843; -.
DR InParanoid; Q10917; -.
DR OMA; LGYENTP; -.
DR OrthoDB; 464838at2759; -.
DR PhylomeDB; Q10917; -.
DR Reactome; R-CEL-112311; Neurotransmitter clearance.
DR Reactome; R-CEL-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-CEL-197264; Nicotinamide salvaging.
DR Reactome; R-CEL-200425; Carnitine metabolism.
DR Reactome; R-CEL-2161517; Abacavir transmembrane transport.
DR Reactome; R-CEL-442660; Na+/Cl- dependent neurotransmitter transporters.
DR Reactome; R-CEL-549127; Organic cation transport.
DR Reactome; R-CEL-561048; Organic anion transport.
DR Reactome; R-CEL-9749641; Aspirin ADME.
DR PRO; PR:Q10917; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00015088; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q10917; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..484
FT /note="Putative transporter B0252.3"
FT /id="PRO_0000050467"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..187
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_009463"
SQ SEQUENCE 484 AA; 53737 MW; B41AA34239699B05 CRC64;
MQVRWAPSDG SLGDYTYQQD MSSSDKLSAD DVLNTLDKSN RHILTCILVC GLAWSPLAFT
GLCPSFVVKA SENSSFIGVA DEFDLTGDAS WLAESTTTFY MVGNMIGGMF IPPLADHYGR
LPVFVATVLL MAVGGMISAF STSIMMFCIM RMIHGIFYTA AGLAGWVLGY ENTPLRLRFF
TSVYFGVMWV VGACFLGLLA YILPDWRYLM FCISVPNIFV ALLIYMTVPE SLHFLVSSQQ
NEKIEAWLEK IRGPKGDISA SDIVEDRDEN GSSFKTLCRE MWKHKMFIVY VLVMTYIWIV
DTFIYFGLAF YSTNLAGNLY LNFVLMSLVE APAYIFSPIF MNKYGRKVLI SGTHIIAGLS
FLGIVLSSEA WHIHFWLLGK FAISCSFMSI YMFASEIFPT DGRNKCIGFC ETLSRFGGML
SPYLSHLTAV HALAPAITLS LIAVSGGLLT LILPETLNTK LPSTIAETAS RRQLIDDKSD
SSSN
