CBWD6_HUMAN
ID CBWD6_HUMAN Reviewed; 395 AA.
AC Q4V339;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=COBW domain-containing protein 6 {ECO:0000305};
DE AltName: Full=Cobalamin synthase W domain-containing protein 6;
GN Name=CBWD6 {ECO:0000312|HGNC:HGNC:31978};
GN Synonyms=CBWD7 {ECO:0000312|HGNC:HGNC:31978};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. CobW
CC subfamily. {ECO:0000305}.
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DR EMBL; BX255923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43827.1; -.
DR RefSeq; NP_001078926.1; NM_001085457.1.
DR AlphaFoldDB; Q4V339; -.
DR SMR; Q4V339; -.
DR BioGRID; 569243; 11.
DR IntAct; Q4V339; 6.
DR STRING; 9606.ENSP00000366608; -.
DR GlyGen; Q4V339; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q4V339; -.
DR PhosphoSitePlus; Q4V339; -.
DR BioMuta; CBWD6; -.
DR DMDM; 74753577; -.
DR jPOST; Q4V339; -.
DR MassIVE; Q4V339; -.
DR MaxQB; Q4V339; -.
DR PaxDb; Q4V339; -.
DR PeptideAtlas; Q4V339; -.
DR PRIDE; Q4V339; -.
DR ProteomicsDB; 62277; -.
DR Antibodypedia; 75705; 42 antibodies from 11 providers.
DR DNASU; 644019; -.
DR Ensembl; ENST00000377391.8; ENSP00000366608.4; ENSG00000215126.11.
DR GeneID; 644019; -.
DR KEGG; hsa:644019; -.
DR MANE-Select; ENST00000377391.8; ENSP00000366608.4; NM_001085457.2; NP_001078926.1.
DR UCSC; uc033csb.2; human.
DR CTD; 644019; -.
DR GeneCards; CBWD6; -.
DR HGNC; HGNC:31978; CBWD6.
DR HPA; ENSG00000215126; Low tissue specificity.
DR neXtProt; NX_Q4V339; -.
DR PharmGKB; PA145149332; -.
DR VEuPathDB; HostDB:ENSG00000215126; -.
DR eggNOG; KOG2743; Eukaryota.
DR GeneTree; ENSGT00640000091523; -.
DR InParanoid; Q4V339; -.
DR OMA; HDCHDHH; -.
DR OrthoDB; 1144889at2759; -.
DR PhylomeDB; Q4V339; -.
DR TreeFam; TF332679; -.
DR PathwayCommons; Q4V339; -.
DR SignaLink; Q4V339; -.
DR BioGRID-ORCS; 644019; 38 hits in 587 CRISPR screens.
DR ChiTaRS; CBWD6; human.
DR GenomeRNAi; 644019; -.
DR Pharos; Q4V339; Tdark.
DR PRO; PR:Q4V339; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q4V339; protein.
DR Bgee; ENSG00000215126; Expressed in cerebellar cortex and 96 other tissues.
DR ExpressionAtlas; Q4V339; baseline and differential.
DR Genevisible; Q4V339; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1220.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR011629; Cbl_biosynth_CobW-like_C.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..395
FT /note="COBW domain-containing protein 6"
FT /id="PRO_0000316774"
FT DOMAIN 274..377
FT /note="CobW C-terminal"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 49..56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 110..114
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 203..206
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 395 AA; 43964 MW; 1F406D7A204028B1 CRC64;
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI
ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTL RSINGLGQIL ETQRSRVDLS
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFD VPGNAKEEHL NMFIQNLLWE
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELCDL EETPVSWKDD TERTNRLVLI
GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
