YTFF_ECOLI
ID YTFF_ECOLI Reviewed; 321 AA.
AC P39314; Q2M695;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Inner membrane protein YtfF;
GN Name=ytfF; OrderedLocusNames=b4210, JW4168;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97106.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE78211.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97106.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77167.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78211.1; ALT_INIT; Genomic_DNA.
DR PIR; S56435; S56435.
DR RefSeq; NP_418631.2; NC_000913.3.
DR RefSeq; WP_001350569.1; NZ_LN832404.1.
DR AlphaFoldDB; P39314; -.
DR SMR; P39314; -.
DR BioGRID; 4263163; 200.
DR STRING; 511145.b4210; -.
DR TCDB; 2.A.7.3.19; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; P39314; -.
DR PRIDE; P39314; -.
DR EnsemblBacteria; AAC77167; AAC77167; b4210.
DR EnsemblBacteria; BAE78211; BAE78211; BAE78211.
DR GeneID; 948732; -.
DR KEGG; ecj:JW4168; -.
DR KEGG; eco:b4210; -.
DR PATRIC; fig|1411691.4.peg.2491; -.
DR EchoBASE; EB2399; -.
DR eggNOG; COG0697; Bacteria.
DR HOGENOM; CLU_058004_0_0_6; -.
DR InParanoid; P39314; -.
DR OMA; WYPLRNA; -.
DR PhylomeDB; P39314; -.
DR BioCyc; EcoCyc:G7867-MON; -.
DR PRO; PR:P39314; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Inner membrane protein YtfF"
FT /id="PRO_0000169824"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..30
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..92
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..154
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..230
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..285
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 13..141
FT /note="EamA"
SQ SEQUENCE 321 AA; 35208 MW; D417608808BD0A3A CRC64;
MISGVLYALL AGLMWGLIFV GPLIVPEYPA MLQSMGRYLA LGLIALPIAW LGRVRLRQLA
RRDWLTALML TMMGNLIYYF CLASAIQRTG APVSTMIIGT LPVVIPVFAN LLYSQRDGKL
AWGKLAPALI CIGIGLACVN IAELNHGLPD FDWARYTSGI VLALVSVVCW AWYALRNARW
LRENPDKHPM MWATAQALVT LPVSLIGYLV ACYWLNTQTP DFSLPFGPRP LVFISLMVAI
AVLCSWVGAL CWNVASQLLP TVILGPLIVF ETLAGLLYTF LLRQQMPPLM TLSGIALLVI
GVVIAVRAKP EKPLTESVSE S
